# PPARG coactivator 1 alpha

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28559561](https://www.wikidata.org/wiki/Q28559561)  
**Source**: https://4ort.xyz/entity/pparg-coactivator-1-alpha-q28559561


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9QYK2)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
5. [Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
6. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
7. [The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4 alpha and cAMP-response element-binding protein (CREB)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
8. [PGC-1α Serine 570 Phosphorylation and GCN5-mediated Acetylation by Angiotensin II Drive Catalase Down-regulation and Vascular Hypertrophy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
9. [Acute exercise modulates the Foxo1/PGC-1alpha pathway in the liver of diet-induced obesity rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
10. [AMP‐activated protein kinase is required for exercise‐induced peroxisome proliferator‐activated receptor γ co‐activator 1α translocation to subsarcolemmal mitochondria in skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
11. [Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
12. [ω-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
13. [Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
14. [Exercise-induced Mitochondrial Biogenesis Begins before the Increase in Muscle PGC-1α Expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
15. [Localization of the transcriptional coactivator PGC-1alpha to GABAergic neurons during maturation of the rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
16. [Quantitative immuno-electron microscopic analysis of depolarization-induced expression of PGC-1α in cultured rat visual cortical neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
17. [The contraction induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1alpha (PGC-1alpha), mitochondrial uncoupling protein 3 (UCP3) and hexokinase II (HKII) in primary rat skeletal muscle cells i](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
18. [Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
19. [Hypoxia-inducible factor-1 (HIF-1)-independent microvascular angiogenesis in the aged rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
20. [17beta-estradiol inhibits oleic acid-induced rat VSMC proliferation and migration by restoring PGC-1alpha expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
21. [Myocardial ischaemic and diazoxide preconditioning both increase PGC-1α and reduce mitochondrial damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
22. [The effect of overexpression of PGC-1α on the mtDNA4834 common deletion in a rat cochlear marginal cell senescence model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
23. [Age-related decline of the cytochrome c oxidase subunit expression in the auditory cortex of the mimetic aging rat model associated with the common deletion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
24. [Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
25. [Activating mitochondrial regulator PGC-1α expression by astrocytic NGF is a therapeutic strategy for Huntington's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
26. [Nuclear SIRT1 activity, but not protein content, regulates mitochondrial biogenesis in rat and human skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
27. [Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
28. [Nandrolone attenuates aortic adaptation to exercise in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
29. [PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
30. [Beneficial effects of omega-3 fatty acids on the consequences of a fructose diet are not mediated by PPAR delta or PGC1 alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
31. [Training‐induced mitochondrial adaptation: role of peroxisome proliferator‐activated receptor γ coactivator‐1α, nuclear factor‐κB and β‐blockade](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
32. [No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: effects are independent of mitochondrial DNA integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
33. [Long-term exercise treatment reduces oxidative stress in the hippocampus of aging rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
34. [Differential regulation of PGC-1alpha expression in rat liver and skeletal muscle in response to voluntary running](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
35. [Xanthine oxidase inhibition attenuates skeletal muscle signaling following acute exercise but does not impair mitochondrial adaptations to endurance training](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
36. [Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
37. [PGC-1α Is a Key Regulator of Glucose-Induced Proliferation and Migration in Vascular Smooth Muscle Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
38. [The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1α expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
39. [The PPARdelta agonist, GW501516, promotes fatty acid oxidation but has no direct effect on glucose utilisation or insulin sensitivity in rat L6 skeletal muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
40. [The key role of PGC-1α in mitochondrial biogenesis and the proliferation of pulmonary artery vascular smooth muscle cells at an early stage of hypoxic exposure](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
41. [Postnatal maternal separation modifies the response to an obesogenic diet in adulthood in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
42. [Energy-sensing Factors Coactivator Peroxisome Proliferator-activated Receptor γ Coactivator 1-α (PGC-1α) and AMP-activated Protein Kinase Control Expression of Inflammatory Mediators in Liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
43. [Leucine Improves Glucose and Lipid Status in Offspring from Obese Dams, Dependent on Diet Type, but not Caloric Intake](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
44. [Atorvastatin Attenuates TNF-α–induced Increase of Glucose Oxidation Through PGC-1α Upregulation in Cardiomyocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
45. [Atorvastatin prevents peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
46. [PPAR-gamma coactivator-1alpha regulates progesterone production in ovarian granulosa cells with SF-1 and LRH-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
47. [Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
48. [Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
49. [Effect of chronic contractile activity on mRNA stability in skeletal muscle](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)
50. [AICAR (5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9QYK2)