# POU domain, class 4, transcription factor 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q21986679](https://www.wikidata.org/wiki/Q21986679)  
**Source**: https://4ort.xyz/entity/pou-domain-class-4-transcription-factor-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q63934)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
5. [A POU Domain Transcription Factor–Dependent Program Regulates Axon Pathfinding in the Vertebrate Visual System](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
6. [Isolation of Three Novel Pou-Domain Containing cDNA Clones from Lactating Mouse Mammary Gland](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934)
8. [Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934)
9. [Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
10. [Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
11. [Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
12. [Early B-Cell Factors Are Required for Specifying Multiple Retinal Cell Types and Subtypes from Postmitotic Precursors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
13. [ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
14. [The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934)
15. [The ability of POU family transcription factors to activate or repress gene expression is dependent on the spacing and context of their specific response elements](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
16. [Isl1 and Pou4f2 Form a Complex to Regulate Target Genes in Developing Retinal Ganglion Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
17. [Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
18. [MouseBRN-3family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity ofBRN-3A](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934)
19. [Brn3 transcription factors control terminal osteoclastogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934)
20. [Isl1 and Pou4f2 Form a Complex to Regulate Target Genes in Developing Retinal Ganglion Cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934)
21. [The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934)
22. [Brn-3.2: A Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934)
23. [Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934)
24. [Brn3 transcription factors control terminal osteoclastogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
25. [The Wilms’ tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
26. [The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
27. [Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
28. [Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
29. [POU Domain Factor Brn-3b Is Essential for Retinal Ganglion Cell Differentiation and Survival but Not for Initial Cell Fate Specification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
30. [Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
31. [Role of transcription factors a Brn-3.1 and Brn-3.2 in auditory and visual system development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
32. [Requirement for Brn-3b in Early Differentiation of Postmitotic Retinal Ganglion Cell Precursors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
33. [Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
34. [A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
35. [Short Isoform of POU Factor Brn-3b Can Form a Heterodimer with Brn-3a That Is Inactive for Octamer Motif Binding](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934)
36. [POU Transcription Factors Brn-3a and Brn-3b Interact with the Estrogen Receptor and Differentially Regulate Transcriptional Activity via an Estrogen Response Element](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q63934&geneProductId=UniProtKB:Q63934)
37. [Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63934)
38. ensembl Release 106