# POU domain, class 4, transcription factor 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21986670](https://www.wikidata.org/wiki/Q21986670)  
**Source**: https://4ort.xyz/entity/pou-domain-class-4-transcription-factor-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P17208)
3. Q20641742
4. [Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
5. [Brn3a target gene recognition in embryonic sensory neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
6. [Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
8. [Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
9. [Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17208&geneProductId=UniProtKB:P17208)
10. [Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17208&geneProductId=UniProtKB:P17208)
11. [Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
12. [Short Isoform of POU Factor Brn-3b Can Form a Heterodimer with Brn-3a That Is Inactive for Octamer Motif Binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
13. [POU Transcription Factors Brn-3a and Brn-3b Interact with the Estrogen Receptor and Differentially Regulate Transcriptional Activity via an Estrogen Response Element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
14. [Brn-3a/POU4F1 interacts with and differentially affects p73-mediated transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
15. [Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17208&geneProductId=UniProtKB:P17208)
16. [Brn3a target gene recognition in embryonic sensory neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17208&geneProductId=UniProtKB:P17208)
17. [Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
18. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P17208&geneProductId=UniProtKB:P17208)
19. [The Different Activities of the Two Activation Domains of the Brn-3a Transcription Factor Are Dependent on the Context of the Binding Site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
20. [Brn3 transcription factors control terminal osteoclastogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
21. [The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
22. [MouseBRN-3family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity ofBRN-3A](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
23. [Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
24. [Brn3a and Nurr1 Mediate a Gene Regulatory Pathway for Habenula Development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
25. [The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
26. [Barhl1 is required for maintenance of a large population of neurons in the zonal layer of the superior colliculus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
27. [POU-domain factor Brn3a regulates both distinct and common programs of gene expression in the spinal and trigeminal sensory ganglia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
28. [Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non‐neural gene expression in the trigeminal ganglion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
29. [Brn3a and Islet1 Act Epistatically to Regulate the Gene Expression Program of Sensory Differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
30. [Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
31. [Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
32. [Brn-3a is required for the generation of proprioceptors in the mesencephalic trigeminal tract nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
33. [The Brn-3a Transcription Factor Induces Neuronal Process Outgrowth and the Coordinate Expression of Genes Encoding Synaptic Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
34. [Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17208)
35. ensembl Release 106