# POU class 4 homeobox 2

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21134896](https://www.wikidata.org/wiki/Q21134896)  
**Source**: https://4ort.xyz/entity/pou-class-4-homeobox-2-q21134896


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q12837)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837)
6. [Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837)
7. [Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837)
8. [Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837)
9. [Proliferation-associated Brn-3b transcription factor can activate cyclin D1 expression in neuroblastoma and breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837)
10. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837)
11. [RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837)
12. [Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837)
13. [Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837)
14. [Genome-Wide Analysis of Histidine Repeats Reveals Their Role in the Localization of Human Proteins to the Nuclear Speckles Compartment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12837)
15. [Genome-Wide Analysis of Histidine Repeats Reveals Their Role in the Localization of Human Proteins to the Nuclear Speckles Compartment](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837)
16. [RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12837&geneProductId=UniProtKB:Q12837)
17. Ensembl Release 99
18. UMLS 2023