# Potassium voltage-gated channel subfamily Q member 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q6449560](https://www.wikidata.org/wiki/Q6449560)  
**Source**: https://4ort.xyz/entity/potassium-voltage-gated-channel-subfamily-q-member-1-q6449560


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL821)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL41355)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P51787)
6. Q20641742
7. [KCNQ1 gain-of-function mutation in familial atrial fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
8. [IKs Gain- and Loss-of-Function in Early-Onset Lone Atrial Fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
9. [Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
10. [Mutation of an A-kinase-anchoring protein causes long-QT syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
11. [Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
13. [The KCNQ1 (Kv7.1) COOH terminus, a multitiered scaffold for subunit assembly and protein interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
14. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
15. [Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
16. [Suppression of Slow Delayed Rectifier Current by a Truncated Isoform of KvLQT1 Cloned from Normal Human Heart](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
17. [The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
18. [Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
19. [Phosphorylation of the A-kinase-anchoring protein Yotiao contributes to protein kinase A regulation of a heart potassium channel](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
20. [Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
21. [KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
22. [Analysis of the interactions between the C-terminal cytoplasmic domains of KCNQ1 and KCNE1 channel subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
23. [Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
24. [KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
25. [Cellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano–Ward syndrome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
26. [KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
27. [Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
28. [A molecular mechanism for adrenergic-induced long QT syndrome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
29. [A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
30. [Long QT mutations at the interface between KCNQ1 helix C and KCNE1 disrupt I(KS) regulation by PKA and PIP₂](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
31. [Mutations in the hminK gene cause long QT syndrome and suppress lKs function](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
32. [Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
33. [Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
34. [AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
35. [Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
36. [Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
37. [Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
38. [Oestrogen promotes KCNQ1 potassium channel endocytosis and postendocytic trafficking in colonic epithelium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
39. [Intracellular domains interactions and gated motions of I(KS) potassium channel subunits](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
40. [KCNQ1 gain-of-function mutation in familial atrial fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
41. [Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?protein=P51787&geneProductId=UniProtKB:P51787)
42. [The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4/Nedd4-like family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
43. [Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
44. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
45. [A molecular mechanism for adrenergic-induced long QT syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
46. [A KCNQ1 mutation contributes to the concealed type 1 long QT phenotype by limiting the Kv7.1 channel conformational changes associated with protein kinase A phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
47. [Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
48. [Mutations in the hminK gene cause long QT syndrome and suppress lKs function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
49. [Augmented potassium current is a shared phenotype for two genetic defects associated with familial atrial fibrillation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)
50. [AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK channel complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51787)