# Potassium voltage-gated channel subfamily H member 2

> mammalian protein found in humans

**Wikidata**: [Q905000](https://www.wikidata.org/wiki/Q905000)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/KCNH2)  
**Source**: https://4ort.xyz/entity/potassium-voltage-gated-channel-subfamily-h-member-2


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL821)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1700)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q12809)
6. Q20641742
7. Freebase Data Dumps. 2013
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
9. [The human delta1261 mutation of the HERG potassium channel results in a truncated protein that contains a subunit interaction domain and decreases the channel expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
10. [The regulation of the cardiac potassium channel (HERG) by caveolin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
11. [RING finger protein RNF207, a novel regulator of cardiac excitation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
12. [Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
13. [14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
14. [Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
15. [Rescue of Aberrant Gating by a Genetically Encoded PAS (Per-Arnt-Sim) Domain in Several Long QT Syndrome Mutant Human Ether-á-go-go-related Gene Potassium Channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
16. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809)
17. [The S1 helix critically regulates the finely tuned gating of Kv11.1 channels](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809)
18. [14-3-3 amplifies and prolongs adrenergic stimulation of HERG K+ channel activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809)
19. [Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809)
20. [Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
21. [A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
22. [I Kr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
23. [The inward rectification mechanism of the HERG cardiac potassium channel](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
24. [HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
25. [The S1 helix critically regulates the finely tuned gating of Kv11.1 channels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
26. [Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
27. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
28. [Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809)
29. [The inward rectification mechanism of the HERG cardiac potassium channel](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809)
30. [RING finger protein RNF207, a novel regulator of cardiac excitation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809)
31. [A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809)
32. [HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12809&geneProductId=UniProtKB:Q12809)
33. [A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12809)
34. Ensembl Release 99
35. UMLS 2023
36. Transporter Classification database
37. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)