Potassium calcium-activated channel subfamily N member 2
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: tetraethylammonium
additional property: PropertyValue
  property ID: P129
  value: tubocurarine
additional property: PropertyValue
  property ID: P361
  value: SK, calmodulin-binding domain superfamily
additional property: PropertyValue
  property ID: P361
  value: small conductance calcium-activated potassium channel
additional property: PropertyValue
  property ID: P361
  value: voltage-gated ion channel
additional property: PropertyValue
  property ID: P527
  value: Calmodulin-binding domain
additional property: PropertyValue
  property ID: P527
  value: Potassium channel domain
additional property: PropertyValue
  property ID: P637
  value: NP_001265133
additional property: PropertyValue
  property ID: P637
  value: NP_067627
additional property: PropertyValue
  property ID: P637
  value: NP_740721
additional property: PropertyValue
  property ID: P680
  value: protein homodimerization activity
additional property: PropertyValue
  property ID: P680
  value: protein domain specific binding
additional property: PropertyValue
  property ID: P680
  value: calcium-activated potassium channel activity
additional property: PropertyValue
  property ID: P681
  value: integral component of membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: cell surface
additional property: PropertyValue
  property ID: P682
  value: ion transport
additional property: PropertyValue
  property ID: P682
  value: potassium ion transport
additional property: PropertyValue
  property ID: P682
  value: regulation of potassium ion transmembrane transport
additional property: PropertyValue
  property ID: P702
  value: KCNN2
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000264773
additional property: PropertyValue
  property ID: P705
  value: ENSP00000421439
additional property: PropertyValue
  property ID: P705
  value: ENSP00000427120
additional property: PropertyValue
  property ID: P7260
  value: 1.A.1.16.1
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 21
      unique citations norm: 0.008
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 21
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q410728
    source count: 1
    confidence: 0.2
    value label: tetraethylammonium
  P129:
    value: Q421268
    source count: 1
    confidence: 0.2
    value label: tubocurarine
  P352:
    value: Q9H2S1
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797251
    source count: 1
    confidence: 0.2
    value label: SK, calmodulin-binding domain superfamily
  P361:
    value: Q7390712
    source count: 1
    confidence: 0.2
    value label: small conductance calcium-activated potassium channel
  P361:
    value: Q354550
    source count: 1
    confidence: 0.2
    value label: voltage-gated ion channel
  P361:
    value: Q5023049
    source count: 1
    confidence: 0.2
    value label: calmodulin-binding proteins
  P361:
    value: Q83133767
    source count: 1
    confidence: 0.2
    value label: Potassium channel domain, protein family
  P527:
    value: Q24722761
    source count: 1
    confidence: 0.2
    value label: Calmodulin-binding domain
  P527:
    value: Q24722427
    source count: 1
    confidence: 0.2
    value label: Potassium channel domain
  P637:
    value: NP_001265133
    source count: 1
    confidence: 0.2
  P637:
    value: NP_067627
    source count: 1
    confidence: 0.2
  P637:
    value: NP_740721
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011541691
    source count: 1
    confidence: 0.2
  P637:
    value: XP_016864946
    source count: 1
    confidence: 0.2
  P680:
    value: Q14762996
    source count: 1
    confidence: 0.2
    value label: protein homodimerization activity
  P680:
    value: Q14860854
    source count: 1
    confidence: 0.2
    value label: protein domain specific binding
  P680:
    value: Q21106296
    source count: 2
    confidence: 0.4
    value label: calcium-activated potassium channel activity
  P680:
    value: Q14819275
    source count: 3
    confidence: 0.6
    value label: calmodulin binding
  P680:
    value: Q14905738
    source count: 1
    confidence: 0.2
    value label: alpha-actinin binding
  P681:
    value: Q14327652
    source count: 3
    confidence: 0.6
    value label: integral component of membrane

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q189094
source count: 1
confidence: 0.2
value label: cell surface

value: Q14645696
source count: 1
confidence: 0.2
value label: soma

value: Q29548
source count: 3
confidence: 0.6
value label: plasma membrane

value: Q14859673
source count: 1
confidence: 0.2
value label: ion transport

value: Q14860315
source count: 2
confidence: 0.4
value label: potassium ion transport

value: Q14905768
source count: 1
confidence: 0.2
value label: regulation of potassium ion transmembrane transport

value: Q14865157
source count: 3
confidence: 0.6
value label: potassium ion transmembrane transport

value: Q22292782
source count: 1
confidence: 0.2
value label: membrane repolarization during atrial cardiac muscle cell action potential

value: Q18028224
source count: 1
confidence: 0.2
value label: KCNN2

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000264773
source count: 1
confidence: 0.2

value: ENSP00000421439
source count: 1
confidence: 0.2

value: ENSP00000427120
source count: 1
confidence: 0.2

value: ENSP00000483124
source count: 1
confidence: 0.2

value: ENSP00000421095
source count: 1
confidence: 0.2

value: 1.A.1.16.1
source count: 2
confidence: 0.4

source: Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2
stated in qid: Q24316491
retrieved: 2019-04-08

source: Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel)
stated in qid: Q24322958
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Functional interaction with filamin A and intracellular Ca 2+ enhance the surface membrane expression of a small-conductance Ca 2+ -activated K + (SK2) channel
stated in qid: Q28115145
retrieved: 2019-04-08

source: Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization
stated in qid: Q24290258
retrieved: 2018-07-16

source: Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation
stated in qid: Q28118782
retrieved: 2018-07-16

source: Alpha-actinin2 cytoskeletal protein is required for the functional membrane localization of a Ca2+-activated K+ channel (SK2 channel)
stated in qid: Q24322958
retrieved: 2018-07-16

source: GOA
stated in qid: Q28018111
retrieved: 2018-07-16

source: Functional interaction with filamin A and intracellular Ca 2+ enhance the surface membrane expression of a small-conductance Ca 2+ -activated K + (SK2) channel
stated in qid: Q28115145
retrieved: 2018-07-16

source: Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization
stated in qid: Q24290258
retrieved: 2019-04-08

source: Ablation of a Ca2+-activated K+ channel (SK2 channel) results in action potential prolongation in atrial myocytes and atrial fibrillation
stated in qid: Q28118782
retrieved: 2019-04-08

source: Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current
stated in qid: Q29147431
retrieved: 2018-07-16

source: Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current
stated in qid: Q29147431
retrieved: 2019-04-08

source: Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2
stated in qid: Q24316491
retrieved: 2018-07-16

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: IUPHAR/BPS Guide to PHARMACOLOGY
stated in qid: Q17091219
retrieved: 2016-08-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Transporter Classification database
stated in qid: Q142667
retrieved: 2020-03-13

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21119843
domain: protein
level: standard
html url: https://4ort.xyz/entity/potassium-calcium-activated-channel-subfamily-n-member-2
markdown url: https://4ort.xyz/entity/potassium-calcium-activated-channel-subfamily-n-member-2.md
facts url summary: https://4ort.xyz/entity/potassium-calcium-activated-channel-subfamily-n-member-2/facts.json
facts url standard: https://4ort.xyz/entity/potassium-calcium-activated-channel-subfamily-n-member-2/facts.json
facts url full: https://4ort.xyz/entity/potassium-calcium-activated-channel-subfamily-n-member-2/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T19:57:36.308068Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:25:14.046139+00:00Z