# Polycystin 2, transient receptor potential cation channel

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21103321](https://www.wikidata.org/wiki/Q21103321)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Polycystin_2)  
**Source**: https://4ort.xyz/entity/polycystin-2-transient-receptor-potential-cation-channel


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q13563)
3. Q20641742
4. [Specific association of the gene product of PKD2 with the TRPC1 channel](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
5. [The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
6. [Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
8. [Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
9. [Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
10. [Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
11. [Polycystin-2 is an intracellular calcium release channel](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
12. [Polycystin-2 interacts with troponin I, an angiogenesis inhibitor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
13. [Troponin I binds polycystin-L and inhibits its calcium-induced channel activation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
14. [PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
15. [Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
16. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
17. [Structural and molecular basis of the assembly of the TRPP2/PKD1 complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
18. [A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
19. [Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
20. [PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
21. [Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
22. [PKD1 interacts with PKD2 through a probable coiled-coil domain](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
23. [Alpha-actinin associates with polycystin-2 and regulates its channel activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
24. [PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
25. [Macromolecular assembly of polycystin-2 intracytosolic C-terminal domain.](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
26. [A high‐resolution structure of the EF‐hand domain of human polycystin‐2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
27. [Function and regulation of TRPP2 ion channel revealed by a gain-of-function mutant](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
28. [The cAMP Signaling Pathway and Direct Protein Kinase A Phosphorylation Regulate Polycystin-2 (TRPP2) Channel Function](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
29. [Effect of hydro-osmotic pressure on polycystin-2 channel function in the human syncytiotrophoblast](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
30. [The human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-termini](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
31. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
32. [Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
33. [Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
34. [Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
35. [Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
36. [Association of PKD2 (polycystin 2) mutations with left-right laterality defects](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
37. [Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
38. [Polycystin-2 down-regulates cell proliferation via promoting PERK-dependent phosphorylation of eIF2alpha](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
39. [Centrosome overduplication and mitotic instability in PKD2 transgenic lines](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
40. [Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
41. [Reactive oxygen species inhibit polycystin-2 (TRPP2) cation channel activity in term human syncytiotrophoblast](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563)
42. Ensembl Release 99
43. Identifiers.org
44. Transporter Classification database