# Polycystin 2, transient receptor potential cation channel

> mammalian protein found in Mus musculus

**Wikidata**: [Q21985207](https://www.wikidata.org/wiki/Q21985207)  
**Source**: https://4ort.xyz/entity/polycystin-2-transient-receptor-potential-cation-channel-q21985207


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O35245)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
5. [Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
6. [Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
7. [Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
8. [Nek8 regulates the expression and localization of polycystin-1 and polycystin-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
9. [Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
10. [PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
11. [Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
12. [Molecular cloning, genomic structure, and protein characterization of mouse optineurin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
13. [In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
14. [Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
15. [Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
16. [Polycystin-2 is regulated by endoplasmic reticulum-associated degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
17. [Identification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
18. [The native TRPP2-dependent channel of murine renal primary cilia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
19. [PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245)
20. [The native TRPP2-dependent channel of murine renal primary cilia](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245)
21. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245)
22. [Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245)
23. [Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245)
25. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
26. [Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
27. [Alpha-actinin associates with polycystin-2 and regulates its channel activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
28. [Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
29. [A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
30. [Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
31. [A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
32. [Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
33. [Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
34. [A splice form of polycystin-2, lacking exon 7, does not interact with polycystin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
35. [The Centrosomal Protein Pericentrin Identified at the Basal Body Complex of the Connecting Cilium in Mouse Photoreceptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
36. [PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
37. [Localization of transient receptor potential ion channels in primary and motile cilia of the female murine reproductive organs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
38. [Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
39. [Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245)
40. [Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
41. [A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245)
42. [Cardiac defects and renal failure in mice with targeted mutations in Pkd2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
43. [Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
44. [Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
45. [Pkd1 and Pkd2 are required for normal placental development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
46. [The ion channel polycystin-2 is required for left-right axis determination in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35245)
47. [Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O35245&geneProductId=UniProtKB:O35245)
48. ensembl Release 106