# Poly(ADP-ribose) polymerase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21112674](https://www.wikidata.org/wiki/Q21112674)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/PARP1)  
**Source**: https://4ort.xyz/entity/poly-adp-ribose-polymerase-1


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P09874)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
6. [Human nuclear NAD+ ADP-ribosyltransferase(polymerizing): organization of the gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P09874&geneProductId=UniProtKB:P09874)
8. [Cooperation of the Cockayne syndrome group B protein and poly(ADP-ribose) polymerase 1 in the response to oxidative stress.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
9. [A role of DNA-PK for the metabolic gene regulation in response to insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
10. [Serine ADP-Ribosylation Depends on HPF1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
11. [Nuclear cGAS suppresses DNA repair and promotes tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
12. [HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
13. [Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
14. [Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
15. [Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
16. [Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
17. [Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
18. [Aprataxin, a novel protein that protects against genotoxic stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
19. [Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
20. [WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
21. [Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
22. [ZNF365 promotes stalled replication forks recovery to maintain genome stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
23. [hPuf-A/KIAA0020 Modulates PARP-1 Cleavage upon Genotoxic Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
24. [PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
25. [A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
26. [BAL1 and Its Partner E3 Ligase, BBAP, Link Poly(ADP-Ribose) Activation, Ubiquitylation, and Double-Strand DNA Repair Independent of ATM, MDC1, and RNF8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
27. [S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
28. [Solution structures of the two PBZ domains from human APLF and their interaction with poly(ADP-ribose)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
29. [PARP-1 transcriptional activity is regulated by sumoylation upon heat shock](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
30. [PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
31. [Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
32. [Physical and functional interaction of the Werner syndrome protein with poly‐ADP ribosyl transferase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
33. [Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
34. [The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
35. [Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
36. [Poly(ADP-ribose)-dependent regulation of Snail1 protein stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
37. [A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
38. [Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
39. [In prostate cancer cells the interaction of C/EBPalpha with Ku70, Ku80, and poly(ADP-ribose) polymerase-1 increases sensitivity to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
40. [Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
41. [Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
42. [Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
43. [Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
44. [Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
45. [Systematic identification of molecular links between core and candidate genes in breast cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
46. [The FHA domain of aprataxin interacts with the C-terminal region of XRCC1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
47. [Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
48. [Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
49. [TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)
50. [Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09874)