# Polo like kinase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21131841](https://www.wikidata.org/wiki/Q21131841)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/PLK1)  
**Source**: https://4ort.xyz/entity/polo-like-kinase-1


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL513909)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1908394)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1738758)
5. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P53350)
6. Q20641742
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
8. [Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
9. [Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
10. [MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
11. [Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
12. [Polo-like kinase 1 phosphorylation of p150 Glued facilitates nuclear envelope breakdown during prophase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
13. [Plk1-mediated phosphorylation of Topors regulates p53 stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
14. [sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
15. [TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
16. [Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
17. [Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
18. [Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
19. [The tumor suppressor CYLD regulates entry into mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
20. [Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
21. [HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
22. [A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
23. [Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
24. [Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
25. [Phosphorylation of Right Open Reading Frame 2 (Rio2) Protein Kinase by Polo-like Kinase 1 Regulates Mitotic Progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
26. [Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
27. [Active cyclin B1-Cdk1 first appears on centrosomes in prophase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
28. [Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
29. [Ubiquitylation-dependent localization of PLK1 in mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
30. [Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
31. [Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
32. [The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
33. [Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
34. [Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
35. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
36. [The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
37. [Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
38. [Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide‐induced mitotically arrested cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
39. [Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
40. [Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
41. [Final stages of cytokinesis and midbody ring formation are controlled by BRUCE](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
42. [Phosphorylation by polo-like kinase 1 induces the tumor-suppressing activity of FADD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
43. [Interaction of chromatin-associated Plk1 and Mcm7](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
44. [MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
45. [Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
46. [Systematic analysis of human protein complexes identifies chromosome segregation proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
47. [An organelle-specific protein landscape identifies novel diseases and molecular mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
48. [Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
49. [A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)
50. [Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350)