# PML nuclear body scaffold

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21106974](https://www.wikidata.org/wiki/Q21106974)  
**Source**: https://4ort.xyz/entity/pml-nuclear-body-scaffold


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P29590)
3. Q20641742
4. [The mechanisms of PML-nuclear body formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590)
5. [Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590)
6. [The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto-oncoprotein PML](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
8. [Cellular Localization, Expression, and Structure of the Nuclear Dot Protein 52](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
9. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590)
10. [The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
11. [Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
12. [SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
13. [Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
14. [Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
15. [PML regulates p53 stability by sequestering Mdm2 to the nucleolus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
16. [The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
17. [Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
18. [PML regulates PER2 nuclear localization and circadian function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
19. [PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
20. [The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
21. [Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
22. [BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
23. [MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
24. [Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
25. [PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
26. [Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
27. [AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
28. [Structural and Functional Characterization of the Phosphorylation-Dependent Interaction between PML and SUMO1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
29. [Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
30. [SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PML](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
31. [Promyelocytic Leukemia Isoform IV Confers Resistance to Encephalomyocarditis Virus via the Sequestration of 3D Polymerase in Nuclear Bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
32. [Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
33. [Daxx Silencing Sensitizes Cells to Multiple Apoptotic Pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
34. [The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
35. [PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
36. [A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
37. [Moloney murine leukemia virus integrase and reverse transcriptase interact with PML proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
38. [Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
39. [An extended consensus motif enhances the specificity of substrate modification by SUMO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
40. [Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
41. [PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
42. [Sequestration and inhibition of Daxx-mediated transcriptional repression by PML](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
43. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
44. [PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
45. [Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
46. [Toward an understanding of the protein interaction network of the human liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
47. [A CK2-dependent mechanism for degradation of the PML tumor suppressor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
48. [Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
49. [Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)
50. [Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590)