# Pleiotrophin

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28560285](https://www.wikidata.org/wiki/Q28560285)  
**Source**: https://4ort.xyz/entity/pleiotrophin


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P63090)
3. Q20641742
4. [Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
5. [Receptor binding of osteoblast-specific factor 1 (OSF-1/HB-GAM) to human osteosarcoma cells promotes cell attachment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
7. [Upregulation of pleiotrophin expression in rat hepatic stellate cells by PDGF and hypoxia: implications for its role in experimental biliary liver fibrogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
9. [Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
10. [Neuroglycan C, a brain-specific chondroitin sulfate proteoglycan, interacts with pleiotrophin, a heparin-binding growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
11. [Heparin affin regulatory peptide/pleiotrophin negatively affects diverse biological activities in C6 glioma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
12. [HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
13. [6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
14. [Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM).](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
15. [Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
16. [Immunohistochemical localization of pleiotrophin and midkine in the lingual epithelium of the adult rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
17. [Upregulation of Pleiotrophin Gene Expression in Developing Microvasculature, Macrophages, and Astrocytes after Acute Ischemic Brain Injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
18. [Role of HB-GAM (heparin-binding growth-associated molecule) in proliferation arrest in cells of the developing rat limb and its expression in the differentiating neuromuscular system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
19. [Heparin-binding growth factor, pleiotrophin, mediates neuritogenic activity of embryonic pig brain-derived chondroitin sulfate/dermatan sulfate hybrid chains](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
20. [A novel family of heparin-binding growth factors, pleiotrophin and midkine, is expressed in the developing rat cerebral cortex.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
21. [Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
22. [The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
23. [Aging-induced proteostatic changes in the rat hippocampus identify ARP3, NEB2 and BRAG2 as a molecular circuitry for cognitive impairment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
24. [N-syndecan and HB-GAM (heparin-binding growth-associated molecule) associate with early axonal tracts in the rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
25. [Expression of HB-GAM (heparin-binding growth-associated molecules) in the pathways of developing axonal processes in vivo and neurite outgrowth in vitro induced by HB-GAM](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
26. [Alterations of overused supraspinatus tendon: a possible role of glycosaminoglycans and HARP/pleiotrophin in early tendon pathology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
27. [Developmentally regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
28. [Immunocytochemical localization of the heparin-binding growth-associated molecule (HB-GAM) in the developing and adult rat cerebellar cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
29. [Heparan sulphate and HB-GAM (heparin-binding growth-associated molecule) in the development of the thalamocortical pathway of rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
30. [Upregulation of the angiogenic factor heparin affin regulatory peptide by progesterone in rat uterus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
31. [CCN1 promotes the differentiation of endothelial progenitor cells and reendothelialization in the early phase after vascular injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
32. [Effect of heparin-binding growth-associated molecule (HB-GAM) on synaptic transmission and early LTP in rat hippocampal slices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
33. [Involvement of Pleiotrophin in CNTF-mediated differentiation of the late retinal progenitor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
34. [Activity-induced enhancement of HB-GAM expression in rat hippocampal slices](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
35. [1α,25-Dihydroxyvitamin D(3) down-regulates pleiotrophin messenger RNA expression in osteoblast-like cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
36. [Induction of heparin-binding growth-associated molecule expression in reactive astrocytes following hippocampal neuronal injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
37. [The role of heparin-binding growth-associated molecule (HB-GAM) in the postsynaptic induction in cultured muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63090)
38. ensembl Release 106