Platelet derived growth factor subunit A
type: Thing
alternate name: PDGF-1
alternate name: PDGFA
alternate name: platelet-derived growth factor alpha chain
alternate name: Platelet-derived growth factor A chain
alternate name: platelet-derived growth factor A-chain
alternate name: platelet-derived growth factor subunit A
alternate name: platelet-derived growth factor alpha polypeptide
alternate name: PDGF A-chain
alternate name: PDGF subunit A
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P04085
additional property: PropertyValue
  property ID: P361
  value: Cystine-knot cytokine
additional property: PropertyValue
  property ID: P361
  value: Platelet-derived growth factor, N-terminal domain, protein family
additional property: PropertyValue
  property ID: P361
  value: PDGF/VEGF domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Platelet-derived growth factor, N-terminal
additional property: PropertyValue
  property ID: P527
  value: Platelet-derived growth factor, conserved site
additional property: PropertyValue
  property ID: P527
  value: PDGF/VEGF domain
additional property: PropertyValue
  property ID: P637
  value: NP_002598
additional property: PropertyValue
  property ID: P637
  value: NP_148983
additional property: PropertyValue
  property ID: P637
  value: XP_011513717
additional property: PropertyValue
  property ID: P638
  value: 3MJK
additional property: PropertyValue
  property ID: P646
  value: /m/03cv_4z
additional property: PropertyValue
  property ID: P680
  value: collagen binding
additional property: PropertyValue
  property ID: P680
  value: protein homodimerization activity
additional property: PropertyValue
  property ID: P680
  value: platelet-derived growth factor receptor binding
additional property: PropertyValue
  property ID: P681
  value: endoplasmic reticulum lumen
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: Golgi membrane
additional property: PropertyValue
  property ID: P682
  value: hair follicle development
additional property: PropertyValue
  property ID: P682
  value: embryonic lung development
additional property: PropertyValue
  property ID: P682
  value: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
additional property: PropertyValue
  property ID: P702
  value: PDGFA
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000346508
additional property: PropertyValue
  property ID: P705
  value: ENSP00000383889
additional property: PropertyValue
  property ID: P705
  value: ENSP00000383572
additional property: PropertyValue
  property ID: P2888
  value: https://identifiers.org/uniprot:P04085
additional property: PropertyValue
  property ID: P2888
  value: http://purl.uniprot.org/uniprot/P04085
additional property: PropertyValue
  property ID: P2888
  value: https://www.ncbi.nlm.nih.gov/protein/P04085
confidence:
  popularity graph score:
    score: 0.009
    score pct: 1
    tier: established
    components:
      sitelinks: 5
      sitelinks norm: 0.012
      unique citations: 38
      unique citations norm: 0.015
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 5
  unique citations: 38
  monthly pageviews: 0
  yearly pageviews: 35
  pageview trend:
    m: 2026-06
    v: 19
  pageview trend:
    m: 2026-05
    v: 5
  pageview trend:
    m: 2026-04
    v: 11
  popularity:
    sitelinks: 5
    max: 423
    pct: 1.2
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P04085
    source count: 1
    confidence: 0.2
  P361:
    value: Q24783539
    source count: 1
    confidence: 0.2
    value label: Cystine-knot cytokine
  P361:
    value: Q83140591
    source count: 1
    confidence: 0.2
    value label: Platelet-derived growth factor, N-terminal domain, protein family
  P361:
    value: Q83137887
    source count: 1
    confidence: 0.2
    value label: PDGF/VEGF domain, protein family
  P361:
    value: Q95354631
    source count: 1
    confidence: 0.2
    value label: Platelet-derived growth factor, conserved site, protein family
  P527:
    value: Q24771580
    source count: 1
    confidence: 0.2
    value label: Platelet-derived growth factor, N-terminal
  P527:
    value: Q24725287
    source count: 1
    confidence: 0.2
    value label: Platelet-derived growth factor, conserved site
  P527:
    value: Q24743684
    source count: 1
    confidence: 0.2
    value label: PDGF/VEGF domain
  P637:
    value: NP_002598
    source count: 1
    confidence: 0.2
  P637:
    value: NP_148983
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011513717
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011513718
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011513719
    source count: 1
    confidence: 0.2
  P638:
    value: 3MJK
    source count: 1
    confidence: 0.2
  P646:
    value: /m/03cv_4z
    source count: 0
    confidence: 0.0

value: Q14819451
source count: 1
confidence: 0.2
value label: collagen binding

value: Q14762996
source count: 2
confidence: 0.4
value label: protein homodimerization activity

value: Q14878379
source count: 3
confidence: 0.6
value label: platelet-derived growth factor receptor binding

value: Q167149
source count: 2
confidence: 0.4
value label: protein binding

value: Q14877670
source count: 1
confidence: 0.2
value label: platelet-derived growth factor binding

value: Q14633848
source count: 1
confidence: 0.2
value label: endoplasmic reticulum lumen

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q14598778
source count: 1
confidence: 0.2
value label: Golgi membrane

value: Q14645596
source count: 2
confidence: 0.4
value label: extracellular region

value: Q939486
source count: 1
confidence: 0.2
value label: microvillus

value: Q14860117
source count: 1
confidence: 0.2
value label: hair follicle development

value: Q21123232
source count: 1
confidence: 0.2
value label: embryonic lung development

value: Q21108617
source count: 1
confidence: 0.2
value label: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

value: Q14912345
source count: 1
confidence: 0.2
value label: negative chemotaxis

value: Q14876082
source count: 1
confidence: 0.2
value label: regulation of actin cytoskeleton organization

value: Q18030420
source count: 1
confidence: 0.2
value label: PDGFA

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000346508
source count: 1
confidence: 0.2

value: ENSP00000383889
source count: 1
confidence: 0.2

value: ENSP00000383572
source count: 1
confidence: 0.2

value: ENSP00000384673
source count: 1
confidence: 0.2

value: https://identifiers.org/uniprot:P04085
source count: 1
confidence: 0.2

value: http://purl.uniprot.org/uniprot/P04085
source count: 1
confidence: 0.2

value: https://www.ncbi.nlm.nih.gov/protein/P04085
source count: 1
confidence: 0.2

source: Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)
stated in qid: Q24317888
retrieved: 2019-04-08

source: A common PDGF receptor is activated by homodimeric A and B forms of PDGF
stated in qid: Q24339650
retrieved: 2019-04-08

source: cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines
stated in qid: Q24299707
retrieved: 2019-04-08

source: Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
stated in qid: Q24306447
retrieved: 2018-04-24

source: A common PDGF receptor is activated by homodimeric A and B forms of PDGF
stated in qid: Q24339650
retrieved: 2018-04-24

source: PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication
stated in qid: Q24317642
retrieved: 2018-04-24

source: Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network
stated in qid: Q24304309
retrieved: 2019-04-08

source: Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor
stated in qid: Q24337621
retrieved: 2019-04-08

source: Platelet-derived growth factor: identification of constituent polypeptide chains
stated in qid: Q24302439
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
stated in qid: Q24299893
retrieved: 2019-04-08

source: GOA
stated in qid: Q28018111
retrieved: 2018-09-10

source: Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex
stated in qid: Q24623888
retrieved: 2018-04-24

source: Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
stated in qid: Q24306447
retrieved: 2019-04-08

source: PDGF induces c-myc mRNA expression in MG-63 human osteosarcoma cells but does not stimulate cell replication
stated in qid: Q24317642
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation
stated in qid: Q24306572
retrieved: 2019-04-08

source: Platelet-derived growth factor: purification and partial characterization
stated in qid: Q24294123
retrieved: 2019-04-08

source: cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines
stated in qid: Q24299707
retrieved: 2018-04-24

source: PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA
stated in qid: Q24316140
retrieved: 2019-04-08

source: Platelet-Derived Growth Factor β-Receptors Can Both Promote and Inhibit Chemotaxis in Human Vascular Smooth Muscle Cells
stated in qid: Q24315921
retrieved: 2019-04-08

source: Mechanism of action and in vivo role of platelet-derived growth factor
stated in qid: Q22010594
retrieved: 2019-04-08

source: Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells
stated in qid: Q24292157
retrieved: 2018-04-24

source: Vascular endothelial growth factor can signal through platelet-derived growth factor receptors
stated in qid: Q24304294
retrieved: 2018-04-24

source: PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
stated in qid: Q22254096
retrieved: 2019-04-08

source: Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains
stated in qid: Q24292935
retrieved: 2019-04-08

source: Effect of platelet-derived growth factor isoforms in rat metanephric mesenchymal cells
stated in qid: Q24292157
retrieved: 2019-04-08

source: Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
stated in qid: Q24299893
retrieved: 2018-04-24

source: VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
stated in qid: Q24303927
retrieved: 2018-04-24

source: PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
stated in qid: Q22254096
retrieved: 2018-04-24

wikidata id: Q21123233
domain: protein
level: standard
html url: https://4ort.xyz/entity/platelet-derived-growth-factor-subunit-a
markdown url: https://4ort.xyz/entity/platelet-derived-growth-factor-subunit-a.md
facts url summary: https://4ort.xyz/entity/platelet-derived-growth-factor-subunit-a/facts.json
facts url standard: https://4ort.xyz/entity/platelet-derived-growth-factor-subunit-a/facts.json
facts url full: https://4ort.xyz/entity/platelet-derived-growth-factor-subunit-a/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T00:48:17.185961Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-04-10T23:19:49.278477+00:00Z