# Platelet derived growth factor receptor alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21102511](https://www.wikidata.org/wiki/Q21102511)  
**Source**: https://4ort.xyz/entity/platelet-derived-growth-factor-receptor-alpha-q21102511


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P16234)
4. Q20641742
5. [Swiss-Prot](http://www.uniprot.org/uniprot/P16234.txt?version=180)
6. [Vascular endothelial growth factor can signal through platelet-derived growth factor receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
8. [A Reactive Oxygen Species-Mediated, Self-Perpetuating Loop Persistently Activates Platelet-Derived Growth Factor Receptor α](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
9. [Two different subunits associate to create isoform-specific platelet-derived growth factor receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
10. [PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
11. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
12. [Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
13. [The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
14. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
15. [Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
16. [Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16234&geneProductId=UniProtKB:P16234)
18. [Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16234&geneProductId=UniProtKB:P16234)
19. [Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16234&geneProductId=UniProtKB:P16234)
20. [Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16234&geneProductId=UniProtKB:P16234)
21. [Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16234&geneProductId=UniProtKB:P16234)
22. [PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16234&geneProductId=UniProtKB:P16234)
23. [Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
25. [Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
26. [Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
27. [Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
28. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16234&geneProductId=UniProtKB:P16234)
29. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
30. [Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
31. [Mechanism of action and in vivo role of platelet-derived growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
32. [Src family kinases negatively regulate platelet-derived growth factor alpha receptor-dependent signaling and disease progression](http://www.ebi.ac.uk/QuickGO/annotations?protein=P16234&geneProductId=UniProtKB:P16234)
33. [Source](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16234)
34. Ensembl Release 99