Platelet derived growth factor, alpha
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: P20033
additional property: PropertyValue
  property ID: P361
  value: Cystine-knot cytokine
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P361
  value: Platelet-derived growth factor, N-terminal domain, protein family
additional property: PropertyValue
  property ID: P527
  value: PDGF/VEGF domain
additional property: PropertyValue
  property ID: P527
  value: Platelet-derived growth factor, N-terminal
additional property: PropertyValue
  property ID: P527
  value: Platelet-derived growth factor, conserved site
additional property: PropertyValue
  property ID: P637
  value: NP_032834
additional property: PropertyValue
  property ID: P637
  value: XP_006504722
additional property: PropertyValue
  property ID: P637
  value: XP_011239273
additional property: PropertyValue
  property ID: P680
  value: protein homodimerization activity
additional property: PropertyValue
  property ID: P680
  value: collagen binding
additional property: PropertyValue
  property ID: P680
  value: platelet-derived growth factor receptor binding
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: extracellular region
additional property: PropertyValue
  property ID: P681
  value: microvillus
additional property: PropertyValue
  property ID: P682
  value: hair follicle development
additional property: PropertyValue
  property ID: P682
  value: embryonic lung development
additional property: PropertyValue
  property ID: P682
  value: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
additional property: PropertyValue
  property ID: P702
  value: Pdgfa
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000038870
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000075463
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000106521
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 21
      unique citations norm: 0.008
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 21
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: P20033
    source count: 1
    confidence: 0.2
  P361:
    value: Q24783539
    source count: 1
    confidence: 0.2
    value label: Cystine-knot cytokine
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83140591
    source count: 1
    confidence: 0.2
    value label: Platelet-derived growth factor, N-terminal domain, protein family
  P361:
    value: Q83137887
    source count: 1
    confidence: 0.2
    value label: PDGF/VEGF domain, protein family
  P361:
    value: Q95354631
    source count: 1
    confidence: 0.2
    value label: Platelet-derived growth factor, conserved site, protein family
  P527:
    value: Q24743684
    source count: 1
    confidence: 0.2
    value label: PDGF/VEGF domain
  P527:
    value: Q24771580
    source count: 1
    confidence: 0.2
    value label: Platelet-derived growth factor, N-terminal
  P527:
    value: Q24725287
    source count: 1
    confidence: 0.2
    value label: Platelet-derived growth factor, conserved site
  P637:
    value: NP_032834
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006504722
    source count: 1
    confidence: 0.2
  P637:
    value: XP_011239273
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001350200
    source count: 1
    confidence: 0.2
  P637:
    value: XP_030110058
    source count: 1
    confidence: 0.2
  P680:
    value: Q14762996
    source count: 2
    confidence: 0.4
    value label: protein homodimerization activity
  P680:
    value: Q14819451
    source count: 2
    confidence: 0.4
    value label: collagen binding
  P680:
    value: Q14878379
    source count: 3
    confidence: 0.6
    value label: platelet-derived growth factor receptor binding
  P680:
    value: Q14877670
    source count: 1
    confidence: 0.2
    value label: platelet-derived growth factor binding
  P680:
    value: Q14762999
    source count: 1
    confidence: 0.2
    value label: protein heterodimerization activity
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q14645596
    source count: 1
    confidence: 0.2
    value label: extracellular region
  P681:
    value: Q939486
    source count: 1
    confidence: 0.2
    value label: microvillus

value: Q189094
source count: 3
confidence: 0.6
value label: cell surface

value: Q1385443
source count: 2
confidence: 0.4
value label: extracellular space

value: Q14860117
source count: 1
confidence: 0.2
value label: hair follicle development

value: Q21123232
source count: 1
confidence: 0.2
value label: embryonic lung development

value: Q21108617
source count: 2
confidence: 0.4
value label: positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

value: Q14761970
source count: 2
confidence: 0.4
value label: positive regulation of protein kinase B signaling

value: Q14912345
source count: 2
confidence: 0.4
value label: negative chemotaxis

value: Q18252951
source count: 1
confidence: 0.2
value label: Pdgfa

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000038870
source count: 1
confidence: 0.2

value: ENSMUSP00000075463
source count: 1
confidence: 0.2

value: ENSMUSP00000106521
source count: 1
confidence: 0.2

value: ENSMUSP00000106522
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling
stated in qid: Q28213257
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-04-24

source: Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts
stated in qid: Q24313549
retrieved: 2018-04-24

source: Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts
stated in qid: Q24313549
retrieved: 2019-02-14

source: Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle
stated in qid: Q28506996
retrieved: 2019-02-14

source: Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development
stated in qid: Q28508377
retrieved: 2019-02-14

source: Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression
stated in qid: Q28588158
retrieved: 2019-02-14

source: The TRQQKRP motif located near the C-terminus of Rac2 is essential for Rac2 biologic functions and intracellular localization
stated in qid: Q28513723
retrieved: 2019-02-14

source: Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice
stated in qid: Q28508576
retrieved: 2019-02-14

source: A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling
stated in qid: Q28585038
retrieved: 2019-02-14

source: PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis
stated in qid: Q28592272
retrieved: 2019-02-14

source: Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A
stated in qid: Q28590608
retrieved: 2019-02-14

source: Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis
stated in qid: Q28595010
retrieved: 2019-02-14

source: Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor
stated in qid: Q28213698
retrieved: 2019-02-14

source: Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle
stated in qid: Q28506996
retrieved: 2018-04-24

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21990868
domain: protein
level: standard
html url: https://4ort.xyz/entity/platelet-derived-growth-factor-alpha
markdown url: https://4ort.xyz/entity/platelet-derived-growth-factor-alpha.md
facts url summary: https://4ort.xyz/entity/platelet-derived-growth-factor-alpha/facts.json
facts url standard: https://4ort.xyz/entity/platelet-derived-growth-factor-alpha/facts.json
facts url full: https://4ort.xyz/entity/platelet-derived-growth-factor-alpha/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T10:55:26.882885Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:12:27.636059+00:00Z