# PKHD1 ciliary IPT domain containing fibrocystin/polyductin

> mammalian protein found in Homo sapiens

**Wikidata**: [Q905111](https://www.wikidata.org/wiki/Q905111)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Fibrocystin)  
**Source**: https://4ort.xyz/entity/pkhd1-ciliary-ipt-domain-containing-fibrocystin-polyductin


## References

1. UniProt
2. Q20641742
3. Freebase Data Dumps. 2013
4. [Regulation of cell proliferation and apoptosis through fibrocystin-prosaposin interaction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
5. [Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
6. [The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
8. [The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
9. [PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
10. [Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
11. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08F94&geneProductId=UniProtKB:P08F94)
12. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08F94&geneProductId=UniProtKB:P08F94)
13. [Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?protein=P08F94&geneProductId=UniProtKB:P08F94)
14. [Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
16. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
17. [Down-regulation of PKHD1 induces cell apoptosis through PI3K and NF-κB pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
18. [Inhibition of PKHD1 may cause S-phase entry via mTOR signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
19. [PKHD1 gene silencing may cause cell abnormal proliferation through modulation of intracellular calcium in autosomal recessive polycystic kidney disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
20. [NF-kappaB activation is required for apoptosis in fibrocystin/polyductin-depleted kidney epithelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08F94)
21. Ensembl Release 99