# pim-1 proto-oncogene, serine/threonine kinase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21100324](https://www.wikidata.org/wiki/Q21100324)  
**Source**: https://4ort.xyz/entity/pim-1-proto-oncogene-serine-threonine-kinase-q21100324


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1952329)
4. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P11309)
5. Q20641742
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309)
7. [The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309)
8. [Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309)
9. [Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309)
11. [The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309)
12. [Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309)
13. [The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309)
14. [The 44-kDa Pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309)
15. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309)
16. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309)
17. [Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309)
18. [Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309)
19. [The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309)
20. [Interactions between RPS19, mutated in Diamond-Blackfan anemia, and the PIM-1 oncoprotein](http://www.ebi.ac.uk/QuickGO/annotations?protein=P11309&geneProductId=UniProtKB:P11309)
21. [PIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: a further kinase implicated in 1,25-(OH)2D3 signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11309)
22. Ensembl Release 99
23. UMLS 2023