# Phospholipase C, gamma 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28556420](https://www.wikidata.org/wiki/Q28556420)  
**Source**: https://4ort.xyz/entity/phospholipase-c-gamma-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P10686)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
6. [Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
7. [TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIα in rat hippocampal neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
8. [Direct protein-protein interaction between PLCgamma1 and the bradykinin B2 receptor--importance of growth conditions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
9. [AP180 Binds to the C-Terminal SH2 Domain of Phospholipase C-γ1 and Inhibits Its Enzymatic Activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
10. [Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular transport](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
11. [Pleckstrin homology domain of phospholipase C-gamma1 directly binds to 68-kDa neurofilament light chain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
12. [Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
13. [Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
14. [The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
15. [Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
16. [Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
17. [Downstream signaling molecules bind to different phosphorylated immunoreceptor tyrosine-based activation motif (ITAM) peptides of the high affinity IgE receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
18. [Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10686&geneProductId=UniProtKB:P10686)
20. [Phospholipase C-gamma is required for agonist-induced Ca2+ entry](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10686&geneProductId=UniProtKB:P10686)
21. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10686&geneProductId=UniProtKB:P10686)
22. [Small GTPase Ras and Rho expression in rat osteoblasts during spaceflight](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
23. [Polyamines are required for phospholipase C-gamma1 expression promoting intestinal epithelial restitution after wounding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
24. [Polyamines are required for phospholipase C-gamma1 expression promoting intestinal epithelial restitution after wounding](http://www.ebi.ac.uk/QuickGO/annotations?protein=P10686&geneProductId=UniProtKB:P10686)
25. [Activation of H2O2-induced VSOR Cl- currents in HTC cells require phospholipase Cgamma1 phosphorylation and Ca2+ mobilisation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
26. [Regulation of neuronal PLCgamma by chronic morphine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
27. [Phospholipase C-gamma1 is required for the activation of store-operated Ca2+ channels in liver cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
28. [Phospholipase C-gamma is required for agonist-induced Ca2+ entry](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P10686)
29. ensembl Release 106