# Phosphoinositide-3-kinase regulatory subunit 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28559495](https://www.wikidata.org/wiki/Q28559495)  
**Source**: https://4ort.xyz/entity/phosphoinositide-3-kinase-regulatory-subunit-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q63787)
3. Q20641742
4. [Modulating Toll-like receptor mediated signaling by (1-->3)-beta-D-glucan rapidly induces cardioprotection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
6. [PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
7. [Syndapin I and endophilin I bind overlapping proline-rich regions of dynamin I: role in synaptic vesicle endocytosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
8. [Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in l6 myocytes and Fao hepatoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
9. [p68 Sam is a substrate of the insulin receptor and associates with the SH2 domains of p85 PI3K](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
10. [The regulatory subunit of PDE6 interacts with PACSIN in photoreceptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
11. [GABAA receptor-associated phosphoinositide 3-kinase is required for insulin-induced recruitment of postsynaptic GABAA receptors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
12. [Mechanism for differential effect of protein-tyrosine phosphatase 1B on Akt versus mitogen-activated protein kinase in 3T3-L1 adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
13. [Shootin1: A protein involved in the organization of an asymmetric signal for neuronal polarization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
14. [Subtoxic N-methyl-D-aspartate delayed neuronal death in ischemic brain injury through TrkB receptor- and calmodulin-mediated PI-3K/Akt pathway activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
15. [Src-dependent association of Cas and p85 phosphatidylinositol 3'-kinase in v-crk-transformed cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
16. [A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
17. [Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
18. [Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
19. [Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
20. [Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2-associated binder 2 as the major mediator in rat hepatocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
21. [Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
22. [Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
23. [Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activati](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
24. [Insulin signaling through insulin receptor substrate 1 and 2 in normal liver development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
25. [Platelet-derived growth factor-BB-mediated activation of Akt suppresses smooth muscle-specific gene expression through inhibition of mitogen-activated protein kinase and redistribution of serum response factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
26. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
27. [Association of PI3K-Akt signaling pathway with digitalis-induced hypertrophy of cardiac myocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
28. [Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
29. [Dephosphorylation of Akt in C6 cells grown in serum-free conditions corresponds with redistribution of p85/PI3K to the nucleus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
30. [Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI 3-kinase-Akt signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
31. [The modulation of vascular ATP-sensitive K+ channel function via the phosphatidylinositol 3-kinase-Akt pathway activated by phenylephrine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
32. [Activation of phosphoinositide-3 kinase/Akt pathway by FeSO4 in rat cerebral cortex synaptic endings](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
33. [Transduction pathways regulating the trophic effects of Saccharomyces boulardii in rat intestinal mucosa](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
34. [Oncogenic Ras signals through activation of both phosphoinositide 3-kinase and Rac1 to induce c-Jun NH2-terminal kinase-mediated, caspase-independent cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
35. [Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
36. [Phosphatidylinositol 3-kinase/Akt signaling stimulates colonic mucosal cell survival during aging](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
37. [Soybean diet alters the insulin-signaling pathway in the liver of rats recovering from early-life malnutrition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
38. [Maternal and postweaning diet interaction alters hypothalamic gene expression and modulates response to a high-fat diet in male offspring](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
39. [Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
40. [Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
41. [Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
42. [EV71 induces COX‐2 expression via c‐Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP‐1 and NF‐κB in rat brain astrocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
43. [Signal transduction of the protective effect of insulin like growth factor-1 on adriamycin-induced apoptosis in cardiac muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
44. [Chronic 17beta-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
45. [Regulation of the phosphoinositide-3 kinase and mitogen-activated protein kinase signaling pathways by progesterone and its reduced metabolites in the rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
46. [In vivo leptin infusion impairs insulin and leptin signalling in liver and hypothalamus](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
47. [Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
48. [REDD1 is a major target of testosterone action in preventing dexamethasone-induced muscle loss](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
49. [Potential role of growth hormone in impairment of insulin signaling in skeletal muscle, adipose tissue, and liver of rats chronically treated with arginine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)
50. [Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q63787)