# Phosphoinositide-3-kinase regulatory subunit 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7119385](https://www.wikidata.org/wiki/Q7119385)  
**Source**: https://4ort.xyz/entity/phosphoinositide-3-kinase-regulatory-subunit-1-q7119385


## References

1. UniProt
2. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2017974)
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1922094)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2165191)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL3218578)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1684984)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL592445)
8. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1236962)
9. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1234354)
10. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL521851)
11. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL411907)
12. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL2387080)
13. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL586702)
14. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P27986)
15. Q20641742
16. [Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
17. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
18. [Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
19. [Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
20. [TrkA alternative splicing: a regulated tumor-promoting switch in human neuroblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
21. [A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
22. [Ligand-binding properties of the two isoforms of the human insulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
24. [Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
25. [FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
26. [FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
27. [A fluorescent indicator for tyrosine phosphorylation-based insulin signaling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
28. [NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
29. [Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
30. [Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
31. [Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
32. [Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
33. [Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
34. [Localization of the Insulin-like Growth Factor I Receptor Binding Sites for the SH2 Domain Proteins p85, Syp, and GTPase Activating Protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
35. [Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
36. [Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
37. [Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
38. [FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
39. [Involvement of Src tyrosine kinase in Escherichia coli invasion of human brain microvascular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
40. [Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
41. [Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
42. [Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
43. [Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
44. [An inherent role of microtubule network in the action of nuclear receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
45. [High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
46. [Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
47. [Tyrosine phosphorylation-dependent yeast two-hybrid system for the identification of the SH2 domain-binding proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
48. [Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
49. [NMR structure of the N-SH2 of the p85 subunit of phosphoinositide 3-kinase complexed to a doubly phosphorylated peptide reveals a second phosphotyrosine binding site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)
50. [Development and application of a DNA microarray-based yeast two-hybrid system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27986)