# Phosphoinositide-3-kinase regulatory subunit 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21498746](https://www.wikidata.org/wiki/Q21498746)  
**Source**: https://4ort.xyz/entity/phosphoinositide-3-kinase-regulatory-subunit-1-q21498746


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P26450)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
5. [The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
6. [Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
7. [PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
8. [Serine Phosphorylation Sites on IRS2 Activated by Angiotensin II and Protein Kinase C To Induce Selective Insulin Resistance in Endothelial Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
9. [Enkurin is a novel calmodulin and TRPC channel binding protein in sperm](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
10. [PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
11. [LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
12. [Phosphoinositide 3-kinase p85beta regulates invadopodium formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
13. [BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
14. [Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
15. [CDK4 is an essential insulin effector in adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
16. [SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
17. [Protein-protein interaction panel using mouse full-length cDNAs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
18. [NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
19. [Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
20. [Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
21. [A TRAF-like motif of the inducible costimulator ICOS controls development of germinal center TFH cells via the kinase TBK1.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
22. [Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
23. [p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
24. [Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
25. [Bioinformatics and cellular signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
26. [The density of extracellular matrix proteins regulates inflammation and insulin signaling in adipocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
27. [Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
28. [The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
29. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
30. [The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
31. [Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P26450&geneProductId=UniProtKB:P26450)
32. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P26450&geneProductId=UniProtKB:P26450)
33. [Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1-haploinsufficient osteoclast functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
34. [p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
35. [Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26450)
36. [The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P26450&geneProductId=UniProtKB:P26450)
37. ensembl Release 106