# Phosphodiesterase 5A

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28558669](https://www.wikidata.org/wiki/Q28558669)  
**Source**: https://4ort.xyz/entity/phosphodiesterase-5a-q28558669


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O54735)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
6. [Expression of Rat cGMP‐Binding cGMP‐Specific Phosphodiesterase mRNA in Purkinje Cell Layers During Postnatal Neuronal Development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
7. [Increased activity of cGMP-specific phosphodiesterase (PDE5) contributes to resistance to atrial natriuretic peptide natriuresis in the pregnant rat](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
8. [Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
9. [Expression and activity of cGMP-dependent phosphodiesterases is up-regulated by lipopolysaccharide (LPS) in rat peritoneal macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
10. [Increased expression of the cGMP-inhibited cAMP-specific (PDE3) and cGMP binding cGMP-specific (PDE5) phosphodiesterases in models of pulmonary hypertension](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
11. [Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
12. [Effect of sildenafil on acrolein-induced airway inflammation and mucus production in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
13. [Characterization and functional role of androgen-dependent PDE5 activity in the bladder](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
14. [Increased phosphodiesterase-5 expression is involved in the decreased vasodilator response to nitric oxide in cirrhotic rat livers](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
15. [Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
16. [Temporal changes in vascular reactivity in early diabetes mellitus in rats: role of changes in endothelial factors and in phosphodiesterase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54735)
17. ensembl Release 104