# Phosphodiesterase 4D

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21106795](https://www.wikidata.org/wiki/Q21106795)  
**Source**: https://4ort.xyz/entity/phosphodiesterase-4d


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q08499)
4. Q20641742
5. [Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca 2+ Release and Cardiac Contractility, Independently of L-Type Ca 2+ Current](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
7. [PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
8. [Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
9. [Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
11. [Functional specialization of beta-arrestin interactions revealed by proteomic analysis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
12. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
13. [Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
14. [Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
15. [Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
16. [Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
17. [Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
18. [A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
19. [Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
20. [Phosphodiesterases 4D and 7A splice variants in the response of HUVEC cells to TNF-alpha(1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
21. [A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
22. [Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
23. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
24. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
25. [Functional specialization of beta-arrestin interactions revealed by proteomic analysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
26. [Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
27. [Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
28. [Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca 2+ Release and Cardiac Contractility, Independently of L-Type Ca 2+ Current](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
29. [The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
30. [Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
31. [Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
32. [Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08499&geneProductId=UniProtKB:Q08499)
33. [Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08499)
34. Ensembl Release 99
35. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)