Phosphodiesterase 4A
type: Thing
description: mammalian protein found in Homo sapiens
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P129
  value: ibudilast
additional property: PropertyValue
  property ID: P129
  value: rolipram
additional property: PropertyValue
  property ID: P129
  value: YM976
additional property: PropertyValue
  property ID: P352
  value: P27815
additional property: PropertyValue
  property ID: P361
  value: 3'5'-cyclic nucleotide phosphodiesterase
additional property: PropertyValue
  property ID: P361
  value: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
additional property: PropertyValue
  property ID: P361
  value: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family
additional property: PropertyValue
  property ID: P527
  value: 3'5'-cyclic nucleotide phosphodiesterase, conserved site
additional property: PropertyValue
  property ID: P527
  value: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
additional property: PropertyValue
  property ID: P527
  value: HD/PDEase domain
additional property: PropertyValue
  property ID: P637
  value: NP_001104777
additional property: PropertyValue
  property ID: P637
  value: NP_001104778
additional property: PropertyValue
  property ID: P637
  value: NP_001104779
additional property: PropertyValue
  property ID: P638
  value: 2QYK
additional property: PropertyValue
  property ID: P638
  value: 3I8V
additional property: PropertyValue
  property ID: P638
  value: 3TVX
additional property: PropertyValue
  property ID: P680
  value: phosphoric diester hydrolase activity
additional property: PropertyValue
  property ID: P680
  value: cAMP binding
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: ruffle membrane
additional property: PropertyValue
  property ID: P681
  value: perinuclear region of cytoplasm
additional property: PropertyValue
  property ID: P682
  value: sensory perception of smell
additional property: PropertyValue
  property ID: P682
  value: regulation of cAMP-mediated signaling
additional property: PropertyValue
  property ID: P682
  value: cAMP catabolic process
additional property: PropertyValue
  property ID: P702
  value: PDE4A
additional property: PropertyValue
  property ID: P703
  value: Homo sapiens
additional property: PropertyValue
  property ID: P705
  value: ENSP00000293683
additional property: PropertyValue
  property ID: P705
  value: ENSP00000341007
confidence:
  popularity graph score:
    score: 0.003
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 23
      unique citations norm: 0.009
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 23
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P129:
    value: Q261167
    source count: 1
    confidence: 0.2
    value label: ibudilast
  P129:
    value: Q410285
    source count: 1
    confidence: 0.2
    value label: rolipram
  P129:
    value: Q15634080
    source count: 1
    confidence: 0.2
    value label: YM976
  P129:
    value: Q1073333
    source count: 1
    confidence: 0.2
    value label: dyphylline
  P129:
    value: Q21098894
    source count: 1
    confidence: 0.2
    value label: crisaborole
  P352:
    value: P27815
    source count: 1
    confidence: 0.2
  P361:
    value: Q24772781
    source count: 1
    confidence: 0.2
    value label: 3'5'-cyclic nucleotide phosphodiesterase
  P361:
    value: Q41798063
    source count: 1
    confidence: 0.2
    value label: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
  P361:
    value: Q83165423
    source count: 1
    confidence: 0.2
    value label: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, protein family
  P361:
    value: Q83164137
    source count: 1
    confidence: 0.2
    value label: HD/PDEase domain, protein family
  P361:
    value: Q95351042
    source count: 1
    confidence: 0.2
    value label: 3'5'-cyclic nucleotide phosphodiesterase, conserved site, protein family
  P527:
    value: Q24773706
    source count: 1
    confidence: 0.2
    value label: 3'5'-cyclic nucleotide phosphodiesterase, conserved site
  P527:
    value: Q24785962
    source count: 1
    confidence: 0.2
    value label: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
  P527:
    value: Q24784827
    source count: 1
    confidence: 0.2
    value label: HD/PDEase domain
  P637:
    value: NP_001104777
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001104778
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001104779
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001230050
    source count: 1
    confidence: 0.2
  P637:
    value: NP_006193
    source count: 1
    confidence: 0.2

value: 2QYK
source count: 1
confidence: 0.2

value: 3I8V
source count: 1
confidence: 0.2

value: 3TVX
source count: 1
confidence: 0.2

value: Q14865583
source count: 1
confidence: 0.2
value label: phosphoric diester hydrolase activity

value: Q21105005
source count: 1
confidence: 0.2
value label: cAMP binding

value: Q167149
source count: 1
confidence: 0.2
value label: protein binding

value: Q14353168
source count: 1
confidence: 0.2
value label: hydrolase activity

value: Q14865571
source count: 1
confidence: 0.2
value label: 3',5'-cyclic-nucleotide phosphodiesterase activity

value: Q79899
source count: 2
confidence: 0.4
value label: cytoplasm

value: Q14883311
source count: 1
confidence: 0.2
value label: ruffle membrane

value: Q14330632
source count: 2
confidence: 0.4
value label: perinuclear region of cytoplasm

value: Q220599
source count: 2
confidence: 0.4
value label: cytosol

value: Q14353100
source count: 1
confidence: 0.2
value label: cell projection

value: Q14865366
source count: 1
confidence: 0.2
value label: sensory perception of smell

value: Q21119705
source count: 1
confidence: 0.2
value label: regulation of cAMP-mediated signaling

value: Q21105008
source count: 5
confidence: 1.0
value label: cAMP catabolic process

value: Q21105004
source count: 1
confidence: 0.2
value label: regulation of protein kinase A signaling

value: Q828130
source count: 2
confidence: 0.4
value label: signal transduction

value: Q18030406
source count: 1
confidence: 0.2
value label: PDE4A

value: Q15978631
source count: 1
confidence: 0.2
value label: Homo sapiens

value: ENSP00000293683
source count: 1
confidence: 0.2

value: ENSP00000341007
source count: 1
confidence: 0.2

value: ENSP00000370078
source count: 1
confidence: 0.2

value: ENSP00000394754
source count: 1
confidence: 0.2

value: ENSP00000468507
source count: 1
confidence: 0.2

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: Open Targets Platform
stated in qid: Q113138000
retrieved: 2023-08-14

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs
stated in qid: Q24318879
retrieved: 2018-06-05

source: Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10
stated in qid: Q24291131
retrieved: 2018-06-05

source: GOA
stated in qid: Q28018111
retrieved: 2018-06-05

source: Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2
stated in qid: Q24317630
retrieved: 2018-06-05

source: Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D
stated in qid: Q24301560
retrieved: 2018-06-05

source: Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2
stated in qid: Q24317630
retrieved: 2019-04-08

source: A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs
stated in qid: Q24318879
retrieved: 2019-04-08

source: Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D
stated in qid: Q24301560
retrieved: 2019-04-08

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-04-08

source: Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10
stated in qid: Q24291131
retrieved: 2019-04-08

source: Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3
stated in qid: Q24337713
retrieved: 2017-10-31

source: The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram
stated in qid: Q28115926
retrieved: 2019-04-08

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2019-11-13

source: IUPHAR/BPS Guide to PHARMACOLOGY
stated in qid: Q17091219
retrieved: 2016-08-17

source: Q20641742
stated in qid: Q20641742
retrieved: 2020-05-30

source: Ensembl Release 99
stated in qid: Q83867711

wikidata id: Q21117805
domain: protein
level: standard
html url: https://4ort.xyz/entity/phosphodiesterase-4a
markdown url: https://4ort.xyz/entity/phosphodiesterase-4a.md
facts url summary: https://4ort.xyz/entity/phosphodiesterase-4a/facts.json
facts url standard: https://4ort.xyz/entity/phosphodiesterase-4a/facts.json
facts url full: https://4ort.xyz/entity/phosphodiesterase-4a/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-24T04:40:51.812279Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:57:03.164433+00:00Z