# Phosphodiesterase 4A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21117805](https://www.wikidata.org/wiki/Q21117805)  
**Source**: https://4ort.xyz/entity/phosphodiesterase-4a


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1752)
4. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL484785)
5. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL19449)
6. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL332750)
7. [Open Targets Platform](https://platform.opentargets.org/drug/CHEMBL1200875)
8. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P27815)
9. Q20641742
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815)
11. [A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815)
12. [Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815)
13. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815)
14. [Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815)
15. [Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815)
16. [Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815)
17. [A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815)
18. [Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815)
19. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815)
20. [Molecular cloning, genomic positioning, promoter identification, and characterization of the novel cyclic amp-specific phosphodiesterase PDE4A10](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815)
21. [Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3](http://www.ebi.ac.uk/QuickGO/annotations?protein=P27815&geneProductId=UniProtKB:P27815)
22. [The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27815)
23. Ensembl Release 99