# Phosphodiesterase 2A

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21105011](https://www.wikidata.org/wiki/Q21105011)  
**Source**: https://4ort.xyz/entity/phosphodiesterase-2a


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O00408)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
6. [Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
8. [Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
9. [Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
10. [Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
11. [Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
12. [Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3′,5′-cyclic nucleotide phosphodiesterase](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
13. [Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
14. [Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
16. [Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3′,5′-cyclic nucleotide phosphodiesterase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
17. [Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
19. [Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
20. [Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
21. [Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
22. [Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
23. [Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
24. [PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
25. [PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
26. [Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
27. [Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
28. [Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3](http://www.ebi.ac.uk/QuickGO/annotations?protein=O00408&geneProductId=UniProtKB:O00408)
29. [Differentiation of human monocytes in vitro with granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor produces distinct changes in cGMP phosphodiesterase expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00408)
30. Ensembl Release 99