# Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

> mammalian protein found in Mus musculus

**Wikidata**: [Q14887711](https://www.wikidata.org/wiki/Q14887711)  
**Source**: https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P42337)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337)
6. [Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337)
7. [Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
9. [The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
10. [Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
11. [Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
12. [Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
13. [Bioinformatics and cellular signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
14. [Involvement of tissue plasminogen activator in onset and effector phases of experimental allergic encephalomyelitis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
15. [Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
16. [Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
17. [The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337)
18. [Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
19. [Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
20. [PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337)
21. [Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
22. [Involvement of heat shock protein (Hsp)90 beta but not Hsp90 alpha in antiapoptotic effect of CpG-B oligodeoxynucleotide](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
23. [PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42337)
24. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42337&geneProductId=UniProtKB:P42337)
25. ensembl Release 106
26. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)