# Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7117823](https://www.wikidata.org/wiki/Q7117823)  
**Source**: https://4ort.xyz/entity/phosphatidylinositol-4-5-bisphosphate-3-kinase-catalytic-subunit-alpha-q7117823


## References

1. UniProt
2. IUPHAR/BPS Guide to PHARMACOLOGY
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P42336)
4. [UniProt](http://www.uniprot.org/uniprot/P42336.txt?167)
5. [Swiss-Prot](http://www.uniprot.org/uniprot/P42336.txt?version=169)
6. Q20641742
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
9. [PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
10. [FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
11. [Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
12. [Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
13. [A frequent kinase domain mutation that changes the interaction between PI3K  and the membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
14. [Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
15. [Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
16. [Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
17. [Mal connects TLR2 to PI3Kinase activation and phagocyte polarization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
18. [C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
19. [Hijacking Dlg1 for Oncogenic Phosphatidylinositol 3-Kinase Activation in Human Epithelial Cells Is a Conserved Mechanism of Human Adenovirus E4-ORF1 Proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
20. [Phospho-tyrosine dependent protein-protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
21. [A human interactome in three quantitative dimensions organized by stoichiometries and abundances](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
22. [Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
23. [The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
24. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42336&geneProductId=UniProtKB:P42336)
25. [Purification and characterization of phosphoinositide 3-kinase from rat liver](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42336&geneProductId=UniProtKB:P42336)
26. [Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
27. [Should individual PI3 kinase isoforms be targeted in cancer?](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
28. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42336&geneProductId=UniProtKB:P42336)
29. [Purification and characterization of phosphoinositide 3-kinase from rat liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
30. [Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P42336&geneProductId=UniProtKB:P42336)
31. [Cardiac regulation by phosphoinositide 3-kinases and PTEN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
32. [Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
33. [IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336)
34. Ensembl Release 99
35. UMLS 2023