# Phosphatase and tensin homolog

> tumor suppressor gene

**Wikidata**: [Q416356](https://www.wikidata.org/wiki/Q416356)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/PTEN_(gene))  
**Source**: https://4ort.xyz/entity/phosphatase-and-tensin-homolog


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P60484)
3. Q20641742
4. Freebase Data Dumps. 2013
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
6. [Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
7. [The lipid phosphatase activity of PTEN is critical for its tumor supressor function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
8. [The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
9. [P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
10. [Critical role for Daxx in regulating Mdm2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
11. [Rak functions as a tumor suppressor by regulating PTEN protein stability and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
12. [X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
13. [NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
14. [PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
15. [Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
16. [TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
17. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
18. [A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
19. [PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
20. [SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
21. [Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
22. [PTEN inhibits BMI1 function independently of its phosphatase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
23. [Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
24. [PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
25. [Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
26. [Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
27. [Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
28. [Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
29. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P60484&geneProductId=UniProtKB:P60484)
30. [The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate](http://www.ebi.ac.uk/QuickGO/annotations?protein=P60484&geneProductId=UniProtKB:P60484)
31. [Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
32. [Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
33. [A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
34. [TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
35. [NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
36. [Subcellular localization of intracellular protein tyrosine phosphatases in T cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
37. [Ubiquitination regulates PTEN nuclear import and tumor suppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
38. [miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
39. [PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
40. [MAGI-2 Inhibits cell migration and proliferation via PTEN in human hepatocarcinoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
41. [The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
42. [PTEN regulation by Akt-EGR1-ARF-PTEN axis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
43. [Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
44. [A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
45. [Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
46. [Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
47. [Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
48. [TGFβ-Stimulated MicroRNA-21 Utilizes PTEN to Orchestrate AKT/mTORC1 Signaling for Mesangial Cell Hypertrophy and Matrix Expansion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
49. [Upregulated microRNA-29a by hepatitis B virus X protein enhances hepatoma cell migration by targeting PTEN in cell culture model](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)
50. [Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60484)