Phosphatase and tensin homolog
type: Thing
description: mammalian protein found in Rattus norvegicus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P352
  value: O54857
additional property: PropertyValue
  property ID: P361
  value: Protein-tyrosine phosphatase-like
additional property: PropertyValue
  property ID: P361
  value: Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
additional property: PropertyValue
  property ID: P361
  value: Tensin phosphatase, C2 domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Protein-tyrosine phosphatase, catalytic
additional property: PropertyValue
  property ID: P527
  value: Protein-tyrosine phosphatase, active site
additional property: PropertyValue
  property ID: P527
  value: Tensin phosphatase, C2 domain
additional property: PropertyValue
  property ID: P637
  value: NP_113794
additional property: PropertyValue
  property ID: P680
  value: phosphatidylinositol-3-phosphatase activity
additional property: PropertyValue
  property ID: P680
  value: phosphoprotein phosphatase activity
additional property: PropertyValue
  property ID: P680
  value: protein serine/threonine phosphatase activity
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P682
  value: angiogenesis
additional property: PropertyValue
  property ID: P682
  value: negative regulation of protein phosphorylation
additional property: PropertyValue
  property ID: P682
  value: regulation of B cell apoptotic process
additional property: PropertyValue
  property ID: P702
  value: Pten
additional property: PropertyValue
  property ID: P703
  value: brown rat
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000028143
additional property: PropertyValue
  property ID: P705
  value: ENSRNOP00000097310
confidence:
  popularity graph score:
    score: 0.005
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 39
      unique citations norm: 0.015
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 39
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: O54857
    source count: 1
    confidence: 0.2
  P361:
    value: Q24743680
    source count: 1
    confidence: 0.2
    value label: Protein-tyrosine phosphatase-like
  P361:
    value: Q24741290
    source count: 1
    confidence: 0.2
    value label: Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
  P361:
    value: Q83165948
    source count: 1
    confidence: 0.2
    value label: Tensin phosphatase, C2 domain, protein family
  P361:
    value: Q83130631
    source count: 1
    confidence: 0.2
    value label: Tensin-type phosphatase domain, protein family
  P361:
    value: Q24768328
    source count: 1
    confidence: 0.2
    value label: Dual specificity phosphatase
  P527:
    value: Q24741554
    source count: 1
    confidence: 0.2
    value label: Protein-tyrosine phosphatase, catalytic
  P527:
    value: Q24783188
    source count: 1
    confidence: 0.2
    value label: Protein-tyrosine phosphatase, active site
  P527:
    value: Q24786850
    source count: 1
    confidence: 0.2
    value label: Tensin phosphatase, C2 domain
  P527:
    value: Q24720256
    source count: 1
    confidence: 0.2
    value label: Tensin-type phosphatase domain
  P637:
    value: NP_113794
    source count: 1
    confidence: 0.2
  P680:
    value: Q14878339
    source count: 2
    confidence: 0.4
    value label: phosphatidylinositol-3-phosphatase activity
  P680:
    value: Q14878340
    source count: 2
    confidence: 0.4
    value label: phosphoprotein phosphatase activity
  P680:
    value: Q21105131
    source count: 1
    confidence: 0.2
    value label: protein serine/threonine phosphatase activity
  P680:
    value: Q14878341
    source count: 3
    confidence: 0.6
    value label: protein tyrosine phosphatase activity
  P680:
    value: Q14878379
    source count: 1
    confidence: 0.2
    value label: platelet-derived growth factor receptor binding
  P681:
    value: Q40260
    source count: 3
    confidence: 0.6
    value label: nucleus
  P681:
    value: Q14817956
    source count: 1
    confidence: 0.2
    value label: nucleoplasm
  P681:
    value: Q79899
    source count: 3
    confidence: 0.6
    value label: cytoplasm
  P681:
    value: Q39572
    source count: 1
    confidence: 0.2
    value label: mitochondrion
  P681:
    value: Q220599
    source count: 2
    confidence: 0.4
    value label: cytosol
  P682:
    value: Q539568
    source count: 1
    confidence: 0.2
    value label: angiogenesis
  P682:
    value: Q14860865
    source count: 1
    confidence: 0.2
    value label: negative regulation of protein phosphorylation

value: Q14878347
source count: 1
confidence: 0.2
value label: regulation of B cell apoptotic process

value: Q14863383
source count: 3
confidence: 0.6
value label: protein dephosphorylation

value: Q14878349
source count: 1
confidence: 0.2
value label: neuron-neuron synaptic transmission

value: Q24422654
source count: 1
confidence: 0.2
value label: Pten

value: Q184224
source count: 1
confidence: 0.2
value label: brown rat

value: ENSRNOP00000028143
source count: 1
confidence: 0.2

value: ENSRNOP00000097310
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-04-08

source: Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase
stated in qid: Q28567492
retrieved: 2019-04-08

source: Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishment
stated in qid: Q28572470
retrieved: 2019-04-08

source: PDZ domains of Par-3 as potential phosphoinositide signaling integrators
stated in qid: Q27649319
retrieved: 2019-04-08

source: Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse
stated in qid: Q28297001
retrieved: 2019-04-08

source: Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN
stated in qid: Q24317335
retrieved: 2019-04-08

source: PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression
stated in qid: Q28565184
retrieved: 2019-04-08

source: PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation
stated in qid: Q29568313
retrieved: 2019-04-08

source: Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.
stated in qid: Q29568322
retrieved: 2019-04-08

source: Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload
stated in qid: Q29568324
retrieved: 2019-04-08

source: Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury
stated in qid: Q28566685
retrieved: 2019-04-08

source: PTEN: a crucial mediator of mitochondria-dependent apoptosis
stated in qid: Q28568382
retrieved: 2019-04-08

source: A role for nuclear PTEN in neuronal differentiation.
stated in qid: Q29568319
retrieved: 2019-04-08

source: PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.
stated in qid: Q48066104
retrieved: 2019-04-08

source: Aging gastropathy-novel mechanisms: hypoxia, up-regulation of multifunctional phosphatase PTEN, and proapoptotic factors
stated in qid: Q28565290
retrieved: 2019-04-08

source: Age-dependent expression of Pten and Smad4 genes in the urogenital system of Wistar rats
stated in qid: Q30273930
retrieved: 2019-04-08

source: In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis
stated in qid: Q28564270
retrieved: 2019-04-08

source: The involvement of PTEN in sleep deprivation-induced memory impairment in rats
stated in qid: Q28579003
retrieved: 2019-04-08

source: Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN
stated in qid: Q28570341
retrieved: 2019-04-08

source: Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN
stated in qid: Q28566493
retrieved: 2019-04-08

source: Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs
stated in qid: Q28564702
retrieved: 2019-04-08

source: Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase/Akt neuroprotective signaling pathway
stated in qid: Q28578296
retrieved: 2019-04-08

source: Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells
stated in qid: Q29568315
retrieved: 2019-04-08

source: Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis
stated in qid: Q28573684
retrieved: 2019-04-08

source: Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway
stated in qid: Q29568312
retrieved: 2019-04-08

source: Inhibition of neuronal phenotype by PTEN in PC12 cells
stated in qid: Q28576729
retrieved: 2019-04-08

source: 17 Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats
stated in qid: Q28583186
retrieved: 2019-04-08

source: Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase
stated in qid: Q29568309
retrieved: 2019-04-08

source: ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages
stated in qid: Q28568956
retrieved: 2019-04-08

source: AMPK regulates K(ATP) channel trafficking via PTEN inhibition in leptin-treated pancreatic β-cells
stated in qid: Q29568323
retrieved: 2019-04-08

wikidata id: Q29525420
domain: protein
level: standard
html url: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q29525420
markdown url: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q29525420.md
facts url summary: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q29525420/facts.json
facts url standard: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q29525420/facts.json
facts url full: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q29525420/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-05T23:22:50.924607Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:26:51.332717+00:00Z