# Phosphatase and tensin homolog

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q29525420](https://www.wikidata.org/wiki/Q29525420)  
**Source**: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q29525420


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O54857)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
5. [Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
6. [Par-3-mediated junctional localization of the lipid phosphatase PTEN is required for cell polarity establishment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
7. [PDZ domains of Par-3 as potential phosphoinositide signaling integrators](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
8. [Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
9. [Phosphorylation of the actin binding protein Drebrin at S647 is regulated by neuronal activity and PTEN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
10. [PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
11. [PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid--mechanistic analysis of a familial Cowden disease-associated PTEN mutation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
12. [Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
13. [Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
14. [Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
15. [PTEN: a crucial mediator of mitochondria-dependent apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
16. [A role for nuclear PTEN in neuronal differentiation.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
17. [PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
18. [Aging gastropathy-novel mechanisms: hypoxia, up-regulation of multifunctional phosphatase PTEN, and proapoptotic factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
19. [Age-dependent expression of Pten and Smad4 genes in the urogenital system of Wistar rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
20. [In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
21. [The involvement of PTEN in sleep deprivation-induced memory impairment in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
22. [Perlecan-induced suppression of smooth muscle cell proliferation is mediated through increased activity of the tumor suppressor PTEN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
23. [Mesangial cell hypertrophy by high glucose is mediated by downregulation of the tumor suppressor PTEN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
24. [Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
25. [Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase/Akt neuroprotective signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
26. [Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
27. [Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
28. [Swimming exercise training-induced left ventricular hypertrophy involves microRNAs and synergistic regulation of the PI3K/AKT/mTOR signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
29. [Inhibition of neuronal phenotype by PTEN in PC12 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
30. [17 Beta-estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
31. [Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
32. [ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
33. [AMPK regulates K(ATP) channel trafficking via PTEN inhibition in leptin-treated pancreatic β-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
34. [Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
35. [Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
36. [Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaR phagocytosis by prostaglandin E2 in alveolar macrophages](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
37. [Regulation of GABAA receptors by fragile X mental retardation protein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
38. [The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O54857)
39. ensembl Release 106