Phosphatase and tensin homolog
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P279
  value: protein
additional property: PropertyValue
  property ID: P352
  value: O08586
additional property: PropertyValue
  property ID: P361
  value: Protein-tyrosine phosphatase-like
additional property: PropertyValue
  property ID: P361
  value: Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
additional property: PropertyValue
  property ID: P361
  value: Tensin phosphatase, C2 domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Tensin phosphatase, C2 domain
additional property: PropertyValue
  property ID: P527
  value: Tensin-type phosphatase domain
additional property: PropertyValue
  property ID: P527
  value: Protein-tyrosine phosphatase, catalytic
additional property: PropertyValue
  property ID: P637
  value: NP_032986
additional property: PropertyValue
  property ID: P637
  value: XP_006526832
additional property: PropertyValue
  property ID: P680
  value: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
additional property: PropertyValue
  property ID: P680
  value: anaphase-promoting complex binding
additional property: PropertyValue
  property ID: P680
  value: protein kinase binding
additional property: PropertyValue
  property ID: P681
  value: nucleus
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: nucleoplasm
additional property: PropertyValue
  property ID: P682
  value: negative regulation of cell population proliferation
additional property: PropertyValue
  property ID: P682
  value: dendritic spine morphogenesis
additional property: PropertyValue
  property ID: P682
  value: locomotory behavior
additional property: PropertyValue
  property ID: P702
  value: Pten
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000013807
confidence:
  popularity graph score:
    score: 0.006
    score pct: 1
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 42
      unique citations norm: 0.017
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 42
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P279:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: O08586
    source count: 1
    confidence: 0.2
  P361:
    value: Q24743680
    source count: 1
    confidence: 0.2
    value label: Protein-tyrosine phosphatase-like
  P361:
    value: Q24741290
    source count: 1
    confidence: 0.2
    value label: Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
  P361:
    value: Q83165948
    source count: 1
    confidence: 0.2
    value label: Tensin phosphatase, C2 domain, protein family
  P361:
    value: Q83130631
    source count: 1
    confidence: 0.2
    value label: Tensin-type phosphatase domain, protein family
  P361:
    value: Q83137584
    source count: 1
    confidence: 0.2
    value label: Protein-tyrosine phosphatase, catalytic domain, protein family
  P527:
    value: Q24786850
    source count: 1
    confidence: 0.2
    value label: Tensin phosphatase, C2 domain
  P527:
    value: Q24720256
    source count: 1
    confidence: 0.2
    value label: Tensin-type phosphatase domain
  P527:
    value: Q24741554
    source count: 1
    confidence: 0.2
    value label: Protein-tyrosine phosphatase, catalytic
  P527:
    value: Q24783188
    source count: 1
    confidence: 0.2
    value label: Protein-tyrosine phosphatase, active site
  P637:
    value: NP_032986
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006526832
    source count: 1
    confidence: 0.2
  P680:
    value: Q14878346
    source count: 4
    confidence: 0.8
    value label: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
  P680:
    value: Q14878343
    source count: 2
    confidence: 0.4
    value label: anaphase-promoting complex binding
  P680:
    value: Q14817984
    source count: 1
    confidence: 0.2
    value label: protein kinase binding
  P680:
    value: Q14878340
    source count: 3
    confidence: 0.6
    value label: phosphoprotein phosphatase activity
  P680:
    value: Q21105131
    source count: 3
    confidence: 0.6
    value label: protein serine/threonine phosphatase activity
  P681:
    value: Q40260
    source count: 6
    confidence: 1.0
    value label: nucleus
  P681:
    value: Q79899
    source count: 6
    confidence: 1.0
    value label: cytoplasm
  P681:
    value: Q14817956
    source count: 2
    confidence: 0.4
    value label: nucleoplasm
  P681:
    value: Q14330629
    source count: 1
    confidence: 0.2
    value label: myelin sheath adaxonal region

value: Q29548
source count: 2
confidence: 0.4
value label: plasma membrane

value: Q14599399
source count: 6
confidence: 1.0
value label: negative regulation of cell population proliferation

value: Q14878369
source count: 4
confidence: 0.8
value label: dendritic spine morphogenesis

value: Q14645719
source count: 2
confidence: 0.4
value label: locomotory behavior

value: Q14819884
source count: 1
confidence: 0.2
value label: response to ethanol

value: Q14820916
source count: 1
confidence: 0.2
value label: response to organic cyclic compound

value: Q14878378
source count: 1
confidence: 0.2
value label: Pten

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000013807
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: Regulation of PTEN Stability and Activity by Plk3
stated in qid: Q28512686
retrieved: 2019-05-09

source: Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
stated in qid: Q28513537
retrieved: 2019-05-09

source: Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells
stated in qid: Q28592252
retrieved: 2019-05-09

source: PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
stated in qid: Q24303571
retrieved: 2019-05-09

source: Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination
stated in qid: Q28591752
retrieved: 2019-05-09

source: PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression
stated in qid: Q28505099
retrieved: 2019-05-09

source: Involvement of PTEN in TPA‐mediated p53‐activation in mouse skin epidermal JB6 cells
stated in qid: Q28586708
retrieved: 2019-05-09

source: Essential role for nuclear PTEN in maintaining chromosomal integrity
stated in qid: Q28513781
retrieved: 2019-05-09

source: The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network
stated in qid: Q39948774
retrieved: 2019-05-09

source: Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis
stated in qid: Q28117749
retrieved: 2019-05-09

source: The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization
stated in qid: Q24650856
retrieved: 2019-05-09

source: Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
stated in qid: Q28590839
retrieved: 2019-05-09

source: Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves
stated in qid: Q28573119
retrieved: 2019-05-09

source: Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain
stated in qid: Q28587414
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2018-07-16

source: Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2
stated in qid: Q28509303
retrieved: 2019-05-09

source: Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression
stated in qid: Q28593244
retrieved: 2019-05-09

source: Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities
stated in qid: Q24303650
retrieved: 2019-05-09

source: Pten knockdown in vivo increases excitatory drive onto dentate granule cells
stated in qid: Q28587622
retrieved: 2019-05-09

source: Pten regulates neuronal arborization and social interaction in mice
stated in qid: Q28512488
retrieved: 2019-05-09

source: Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior
stated in qid: Q28508076
retrieved: 2019-05-09

source: MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue
stated in qid: Q24643939
retrieved: 2019-05-09

source: PTEN degradation after ischemic stroke: a double-edged sword
stated in qid: Q28512531
retrieved: 2019-05-09

source: Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
stated in qid: Q28586004
retrieved: 2019-05-09

source: Analysis of mouse embryonic patterning and morphogenesis by forward genetics
stated in qid: Q28589055
retrieved: 2019-05-09

source: PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
stated in qid: Q28588309
retrieved: 2019-05-09

source: PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility
stated in qid: Q28590466
retrieved: 2019-05-09

source: Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury
stated in qid: Q28506127
retrieved: 2019-05-09

source: A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice
stated in qid: Q28589460
retrieved: 2019-05-09

wikidata id: Q14878408
domain: protein
level: standard
html url: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q14878408
markdown url: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q14878408.md
facts url summary: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q14878408/facts.json
facts url standard: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q14878408/facts.json
facts url full: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q14878408/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-06T14:38:52.610625Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T13:57:37.732274+00:00Z