# Phosphatase and tensin homolog

> mammalian protein found in Mus musculus

**Wikidata**: [Q14878408](https://www.wikidata.org/wiki/Q14878408)  
**Source**: https://4ort.xyz/entity/phosphatase-and-tensin-homolog-q14878408


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O08586)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
5. [Regulation of PTEN Stability and Activity by Plk3](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
6. [Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
7. [Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
8. [PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
9. [Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
10. [PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
11. [Involvement of PTEN in TPA‐mediated p53‐activation in mouse skin epidermal JB6 cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
12. [Essential role for nuclear PTEN in maintaining chromosomal integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
13. [The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
14. [Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
15. [The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
16. [Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
17. [Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
18. [Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O08586&geneProductId=UniProtKB:O08586)
20. [Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
21. [Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
22. [Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
23. [Pten knockdown in vivo increases excitatory drive onto dentate granule cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
24. [Pten regulates neuronal arborization and social interaction in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
25. [Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
26. [MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
27. [PTEN degradation after ischemic stroke: a double-edged sword](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
28. [Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
29. [Analysis of mouse embryonic patterning and morphogenesis by forward genetics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
30. [PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
31. [PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
32. [Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
33. [A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
34. [DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
35. [PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
36. [B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
37. [Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
38. [Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
39. [The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
40. [Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
41. [mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08586)
42. ensembl Release 106