# Period circadian clock 2

> mammalian protein found in Mus musculus

**Wikidata**: [Q15323263](https://www.wikidata.org/wiki/Q15323263)  
**Source**: https://4ort.xyz/entity/period-circadian-clock-2


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O54943)
3. Q20641742
4. [Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
5. [The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
6. [Biochemical analysis of the canonical model for the mammalian circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
7. [A molecular mechanism for circadian clock negative feedback](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
8. [Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
9. [SIRT1 regulates circadian clock gene expression through PER2 deacetylation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
10. [The polycomb group protein EZH2 is required for mammalian circadian clock function](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
11. [Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
12. [Mammalian TIMELESS Is Involved in Period Determination and DNA Damage-Dependent Phase Advancing of the Circadian Clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
13. [Distinct roles of DBHS family members in the circadian transcriptional feedback loop](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
14. [A novel protein, CHRONO, functions as a core component of the mammalian circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
15. [Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
16. [Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
17. [PML regulates PER2 nuclear localization and circadian function](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
18. [Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
19. [Casein kinase 1 delta regulates the pace of the mammalian circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
20. [Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
21. [Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
22. [Molecular analysis of mammalian timeless](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
23. [Feedback Regulation of Transcriptional Termination by the Mammalian Circadian Clock PERIOD Complex](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
24. [Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
25. [Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
26. [Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
27. [SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
28. [Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
29. [CAVIN‐3 regulates circadian period length and PER:CRY protein abundance and interactions](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
30. [FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
31. [High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
32. [Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
33. [Machine Learning Helps Identify CHRONO as a Circadian Clock Component](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
34. [The BMAL1 C terminus regulates the circadian transcription feedback loop.](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
35. [Cryptochromes mediate rhythmic repression of the glucocorticoid receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
36. [Structural and Functional Analyses of PAS Domain Interactions of the Clock Proteins Drosophila PERIOD and Mouse PERIOD2](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
37. [cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
38. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
39. [Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
40. [PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
41. [Loss ofmPer2increases plasma insulin levels by enhanced glucose‐stimulated insulin secretion and impaired insulin clearance in mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
42. [PER2 controls lipid metabolism by direct regulation of PPARγ](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
43. [Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
44. [Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
45. [Cardiac Per2 Functions as Novel Link between Fatty Acid Metabolism and Myocardial Inflammation during Ischemia and Reperfusion Injury of the Heart](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
46. [The Circadian Molecular Clock Regulates Adult Hippocampal Neurogenesis by Controlling the Timing of Cell-Cycle Entry and Exit](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
47. [Mutation of the circadian clock gene Per2 alters vascular endothelial function](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
48. [Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
49. [A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)
50. [Histone acetyltransferase-dependent chromatin remodeling and the vascular clock](http://www.ebi.ac.uk/QuickGO/annotations?protein=O54943&geneProductId=UniProtKB:O54943)