# Paxillin

> mammalian protein found in Homo sapiens

**Wikidata**: [Q7156477](https://www.wikidata.org/wiki/Q7156477)  
**Source**: https://4ort.xyz/entity/paxillin


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P49023)
3. Q20641742
4. [Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
5. [Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49023&geneProductId=UniProtKB:P49023)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
8. [Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
9. [Epithelial protein lost in neoplasm modulates platelet-derived growth factor–mediated adhesion and motility of mesangial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
10. [Brk activates rac1 and promotes cell migration and invasion by phosphorylating paxillin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
11. [Cell adhesion molecule CEACAM1 associates with paxillin in granulocytes and epithelial and endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
12. [TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
13. [Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
14. [Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
15. [Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
16. [Identification of paxilin domains interacting with β‐catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
17. [FAK promotes recruitment of talin to nascent adhesions to control cell motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
18. [Competitive binding to a charged leucine motif represses transformation by a papillomavirus E6 oncoprotein](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
19. [Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
20. [GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
21. [Proinvasion metastasis drivers in early-stage melanoma are oncogenes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
22. [Cyanidin-3-Glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
23. [Roles of Gab1 and SHP2 in paxillin tyrosine dephosphorylation and Src activation in response to epidermal growth factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
24. [Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
25. [RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
26. [Interaction of Hic-5, A Senescence-related Protein, with Focal Adhesion Kinase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
27. [CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
28. [Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein–Protein Interactions in a Pathway Network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
29. [Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
30. [Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
31. [Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
33. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49023&geneProductId=UniProtKB:P49023)
34. [Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49023&geneProductId=UniProtKB:P49023)
35. [Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49023&geneProductId=UniProtKB:P49023)
36. [Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49023&geneProductId=UniProtKB:P49023)
37. [Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes](http://www.ebi.ac.uk/QuickGO/annotations?protein=P49023&geneProductId=UniProtKB:P49023)
38. [Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
39. [Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
40. [Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
41. [Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
42. [Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
43. [Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
44. [The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
45. [Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
46. [Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49023)
47. Ensembl Release 99
48. [Identifiers.org](https://registry.identifiers.org/registry/uniprot)