# Patched 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21989959](https://www.wikidata.org/wiki/Q21989959)  
**Source**: https://4ort.xyz/entity/patched-1-q21989959


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q61115)
3. Q20641742
4. [Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
5. [Patched1 interacts with cyclin B1 to regulate cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
7. [Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
8. [Disruption of Scube2 Impairs Endochondral Bone Formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
9. [Precocious cerebellum development and improved motor functions in mice lacking the astrocyte cilium-, patched 1-associated Gpr37l1 receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
10. [Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
12. [A Spontaneous Mouse Mutation, mesenchymal dysplasia (mes), Is Caused by a Deletion of the Most C-Terminal Cytoplasmic Domain of patched (ptc)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
13. [Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
14. [The hedgehog receptor patched is involved in cholesterol transport](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
15. [Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
16. [The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
17. [Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
18. [Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
19. [GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
20. [Regulation of pancreas development by hedgehog signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
21. [Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
22. [Cilia and Hedgehog responsiveness in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
23. [Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
24. [Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
25. [Defects in mouse mammary gland development caused by conditional haploinsufficiency of Patched-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
26. [Patched1 functions as a gatekeeper by promoting cell cycle progression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
27. [Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
28. [C2cd3 is required for cilia formation and Hedgehog signaling in mouse.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
29. [Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
30. [Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
31. [Combined activities of hedgehog signaling inhibitors regulate pancreas development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
32. [The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
33. [Complex interactions between genes controlling trafficking in primary cilia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
34. [Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
35. [Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
36. [Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61115)
37. ensembl Release 106