# Parkinsonism associated deglycase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21097342](https://www.wikidata.org/wiki/Q21097342)  
**Source**: https://4ort.xyz/entity/parkinsonism-associated-deglycase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q99497)
3. Q20641742
4. [DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
5. [DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
6. [DJ-1 is a copper chaperone acting on SOD1 activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
7. [Oxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
8. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
9. [Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
10. [Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
11. [DJ-1 binds to mitochondrial complex I and maintains its activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
12. [DJ-1 cooperates with PYCR1 in cell protection against oxidative stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
13. [RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
14. [Mitochondrial localization of DJ-1 leads to enhanced neuroprotection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
15. [Structure of Cu(I)-bound DJ-1 reveals a biscysteinate metal binding site at the homodimer interface: insights into mutational inactivation of DJ-1 in Parkinsonism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
16. [Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
17. [Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
18. [DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
19. [Regulation of the VHL/HIF-1 pathway by DJ-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
20. [The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
21. [DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
22. [Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
23. [DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
24. [A proteome-scale map of the human interactome network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
25. [Increased interaction between DJ-1 and the Mi-2/ nucleosome remodelling and deacetylase complex during cellular stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
26. [Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
27. [DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
28. [DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
29. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
30. [Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
31. [Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal- and glyoxal-glycated cysteine, arginine, and lysine residues](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
32. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
33. [E-cadherin interactome complexity and robustness resolved by quantitative proteomics](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
34. [Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
35. [DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
36. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
37. [Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
38. [Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
39. [Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
40. [The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
41. [Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99497)
42. [DJ-1 positively regulates the androgen receptor by impairing the binding of PIASx alpha to the receptor](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
43. [Proteomic characterization of the human sperm nucleus](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
44. [Mitochondrial localization of DJ-1 leads to enhanced neuroprotection](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
45. [Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
46. [DJ-1 binds to mitochondrial complex I and maintains its activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
47. [The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
48. [Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
49. [Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)
50. [Large-scale proteomics and phosphoproteomics of urinary exosomes](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99497&geneProductId=UniProtKB:Q99497)