# Parkinson disease (autosomal recessive, early onset) 7

> mammalian protein found in Mus musculus

**Wikidata**: [Q21989850](https://www.wikidata.org/wiki/Q21989850)  
**Source**: https://4ort.xyz/entity/parkinson-disease-autosomal-recessive-early-onset-7


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q99LX0)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
5. [Park7 interacts with p47(phox) to direct NADPH oxidase-dependent ROS production and protect against sepsis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
6. [hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
7. [DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
8. [DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
9. [Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99LX0&geneProductId=UniProtKB:Q99LX0)
11. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
12. [DJ-1 Cleavage by Matrix Metalloproteinase 3 Mediates Oxidative Stress-Induced Dopaminergic Cell Death](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99LX0&geneProductId=UniProtKB:Q99LX0)
13. [Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99LX0&geneProductId=UniProtKB:Q99LX0)
14. [The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99LX0&geneProductId=UniProtKB:Q99LX0)
15. [Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
16. [A mitochondrial protein compendium elucidates complex I disease biology](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99LX0&geneProductId=UniProtKB:Q99LX0)
17. [DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99LX0&geneProductId=UniProtKB:Q99LX0)
18. [The caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
19. [DJ-1 Cleavage by Matrix Metalloproteinase 3 Mediates Oxidative Stress-Induced Dopaminergic Cell Death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
20. [A mitochondrial protein compendium elucidates complex I disease biology](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
21. [Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
22. [Molecular cloning of human and mouse DJ-1 genes and identification of Sp1-dependent activation of the human DJ-1 promoter](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99LX0&geneProductId=UniProtKB:Q99LX0)
23. [Human DJ-1 and its homologs are novel glyoxalases](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
24. [Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
25. [Regulation of the VHL/HIF-1 pathway by DJ-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
26. [Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
27. [Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
28. [DJ-1 binds to mitochondrial complex I and maintains its activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
29. [Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
30. [Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
31. [DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
32. [Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
33. [Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
34. [Regulation of astrocyte inflammatory responses by the Parkinson's disease-associated gene DJ-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
35. [Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
36. [DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
37. [DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
38. [Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99LX0)
39. ensembl Release 106