# Parkin RBR E3 ubiquitin protein ligase

> mammalian protein found in Homo sapiens

**Wikidata**: [Q2472777](https://www.wikidata.org/wiki/Q2472777)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/Parkin_(protein))  
**Source**: https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/O60260)
3. Q20641742
4. [Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
5. [S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson’s disease](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260)
6. [Structure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of Neuroprotection](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
7. [Parkin interacts with Ambra1 to induce mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
8. [Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
9. [Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
10. [CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
12. [Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
13. [Identification of the Ubiquitin-like Domain of Midnolin as a New Glucokinase Interaction Partner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
14. [Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
15. [Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
16. [PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
17. [Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
18. [Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
19. [Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
20. [Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
21. [Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
22. [Parkin accumulation in aggresomes due to proteasome impairment](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
23. [Parkin is an E3 ubiquitin-ligase for normal and mutant ataxin-2 and prevents ataxin-2-induced cell death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
24. [An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
25. [A Product of the Human Gene Adjacent to parkin Is a Component of Lewy Bodies and Suppresses Pael Receptor-induced Cell Death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
26. [High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
27. [Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
28. [The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
29. [The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
30. [Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
31. [Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
32. [Ataxin-3 is a multivalent ligand for the parkin Ubl domain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
33. [PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
34. [PINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
35. [PINK1-dependent recruitment of Parkin to mitochondria in mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
36. [Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
37. [The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
38. [Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
39. [Towards a proteome-scale map of the human protein–protein interaction network](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
40. [Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
41. [14-3-3eta is a novel regulator of parkin ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
42. [Hepatitis C virus core protein suppresses mitophagy by interacting with parkin in the context of mitochondrial depolarization](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
43. [Cytosolic cleaved PINK 1 represses P arkin translocation to mitochondria and mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
44. [Parkin ubiquitinates and promotes the degradation of RanBP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
45. [PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
46. [An empirical framework for binary interactome mapping](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
47. [BAG5 inhibits parkin and enhances dopaminergic neuron degeneration](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O60260)
48. [An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260)
49. [Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260)
50. [Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?protein=O60260&geneProductId=UniProtKB:O60260)