# Parkin RBR E3 ubiquitin protein ligase

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28558502](https://www.wikidata.org/wiki/Q28558502)  
**Source**: https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q28558502


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9JK66)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
5. [BECN1 is involved in the initiation of mitophagy: it facilitates PARK2 translocation to mitochondria](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
6. [Parkin ubiquitinates and promotes the degradation of RanBP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
7. [Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
8. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
9. [Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
10. [Astrocytic but not neuronal increased expression and redistribution of parkin during unfolded protein stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
11. [CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
12. [Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
13. [Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
14. [Ultrastructural localization of parkin in the rat brainstem, thalamus and basal ganglia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
15. [Parkin and CASK/LIN-2 Associate via a PDZ-mediated Interaction and Are Co-localized in Lipid Rafts and Postsynaptic Densities in Brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
16. [Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
17. [Parkin is associated with cellular vesicles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
18. [Cloning of rat parkin cDNA and distribution of parkin in rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
19. [The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
20. [Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
21. [Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rat brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
22. [The PARK2 gene is involved in the maintenance of pancreatic β-cell functions related to insulin production and secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
23. [Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
24. [Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease?](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
25. [Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
26. [Regulation of hippocampal parkin protein by corticosteroids](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
27. [Pruning and loss of excitatory synapses by the parkin ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
28. [Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
29. [Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
30. [ATF4 Protects Against Neuronal Death in Cellular Parkinson's Disease Models by Maintaining Levels of Parkin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
31. [Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9JK66)
32. ensembl Release 106