Parkin RBR E3 ubiquitin protein ligase
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: Ubiquitin-like domain superfamily
additional property: PropertyValue
  property ID: P361
  value: E3 ubiquitin-protein ligase parkin
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P527
  value: IBR domain
additional property: PropertyValue
  property ID: P527
  value: Ubiquitin domain
additional property: PropertyValue
  property ID: P637
  value: NP_001304655
additional property: PropertyValue
  property ID: P637
  value: NP_057903
additional property: PropertyValue
  property ID: P637
  value: XP_006523399
additional property: PropertyValue
  property ID: P638
  value: 1MG8
additional property: PropertyValue
  property ID: P638
  value: 2ZEQ
additional property: PropertyValue
  property ID: P638
  value: 3B1L
additional property: PropertyValue
  property ID: P680
  value: phospholipase binding
additional property: PropertyValue
  property ID: P680
  value: histone deacetylase binding
additional property: PropertyValue
  property ID: P680
  value: tubulin binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: postsynaptic membrane
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P682
  value: negative regulation of neuron apoptotic process
additional property: PropertyValue
  property ID: P682
  value: negative regulation of insulin secretion
additional property: PropertyValue
  property ID: P682
  value: positive regulation of mitophagy in response to mitochondrial depolarization
additional property: PropertyValue
  property ID: P702
  value: Prkn
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000140587
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000127455
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000136268
confidence:
  popularity graph score:
    score: 0.005
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 35
      unique citations norm: 0.014
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 35
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q9WVS6
    source count: 1
    confidence: 0.2
  P361:
    value: Q24725964
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-like domain superfamily
  P361:
    value: Q24719959
    source count: 1
    confidence: 0.2
    value label: E3 ubiquitin-protein ligase parkin
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83166228
    source count: 1
    confidence: 0.2
    value label: IBR domain, protein family
  P361:
    value: Q83141069
    source count: 1
    confidence: 0.2
    value label: Ubiquitin-like domain, protein family
  P527:
    value: Q24787246
    source count: 1
    confidence: 0.2
    value label: IBR domain
  P527:
    value: Q24773826
    source count: 1
    confidence: 0.2
    value label: Ubiquitin domain
  P637:
    value: NP_001304655
    source count: 1
    confidence: 0.2
  P637:
    value: NP_057903
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006523399
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006523400
    source count: 1
    confidence: 0.2
  P637:
    value: XP_006523402
    source count: 1
    confidence: 0.2
  P638:
    value: 1MG8
    source count: 1
    confidence: 0.2
  P638:
    value: 2ZEQ
    source count: 1
    confidence: 0.2
  P638:
    value: 3B1L
    source count: 1
    confidence: 0.2
  P680:
    value: Q14860858
    source count: 2
    confidence: 0.4
    value label: phospholipase binding
  P680:
    value: Q14865603
    source count: 2
    confidence: 0.4
    value label: histone deacetylase binding
  P680:
    value: Q14762993
    source count: 2
    confidence: 0.4
    value label: tubulin binding
  P680:
    value: Q21096356
    source count: 2
    confidence: 0.4
    value label: cullin family protein binding
  P680:
    value: Q14860298
    source count: 2
    confidence: 0.4
    value label: PDZ domain binding
  P681:
    value: Q79899
    source count: 5
    confidence: 1.0
    value label: cytoplasm

value: Q14864257
source count: 1
confidence: 0.2
value label: postsynaptic membrane

value: Q14349455
source count: 1
confidence: 0.2
value label: membrane

value: Q39572
source count: 6
confidence: 1.0
value label: mitochondrion

value: Q14330632
source count: 2
confidence: 0.4
value label: perinuclear region of cytoplasm

value: Q14820618
source count: 4
confidence: 0.8
value label: negative regulation of neuron apoptotic process

value: Q14864117
source count: 2
confidence: 0.4
value label: negative regulation of insulin secretion

value: Q21095242
source count: 2
confidence: 0.4
value label: positive regulation of mitophagy in response to mitochondrial depolarization

value: Q21100432
source count: 1
confidence: 0.2
value label: positive regulation of mitochondrial fission

value: Q14863044
source count: 1
confidence: 0.2
value label: synaptic transmission, glutamatergic

value: Q14864256
source count: 1
confidence: 0.2
value label: Prkn

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000140587
source count: 1
confidence: 0.2

value: ENSMUSP00000127455
source count: 1
confidence: 0.2

value: ENSMUSP00000136268
source count: 1
confidence: 0.2

value: ENSMUSP00000140217
source count: 1
confidence: 0.2

value: ENSMUSP00000151830
source count: 1
confidence: 0.2

source: GOA
stated in qid: Q28018111
retrieved: 2019-05-09

source: GOA
stated in qid: Q28018111
retrieved: 2018-04-24

source: SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination
stated in qid: Q27658916
retrieved: 2018-04-24

source: PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease
stated in qid: Q24294809
retrieved: 2019-05-09

source: A Product of the Human Gene Adjacent to parkin Is a Component of Lewy Bodies and Suppresses Pael Receptor-induced Cell Death
stated in qid: Q24297163
retrieved: 2019-05-09

source: Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity
stated in qid: Q24297369
retrieved: 2019-05-09

source: SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination
stated in qid: Q27658916
retrieved: 2019-05-09

source: Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models
stated in qid: Q52677940
retrieved: 2019-05-09

source: Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential
stated in qid: Q24297216
retrieved: 2019-05-09

source: 14-3-3eta is a novel regulator of parkin ubiquitin ligase
stated in qid: Q28115387
retrieved: 2019-05-09

source: Parkin ubiquitinates and promotes the degradation of RanBP2
stated in qid: Q24298223
retrieved: 2019-05-09

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-05-09

source: Identification of the Ubiquitin-like Domain of Midnolin as a New Glucokinase Interaction Partner
stated in qid: Q24339313
retrieved: 2018-04-24

source: Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1
stated in qid: Q24308897
retrieved: 2018-04-24

source: Identification of the Ubiquitin-like Domain of Midnolin as a New Glucokinase Interaction Partner
stated in qid: Q24339313
retrieved: 2019-05-09

source: Differential expression and tissue distribution of parkin isoforms during mouse development
stated in qid: Q28590320
retrieved: 2019-05-09

source: Parkin occurs in a stable, non-covalent, approximately 110-kDa complex in brain
stated in qid: Q28505637
retrieved: 2019-05-09

source: Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1
stated in qid: Q24308897
retrieved: 2019-05-09

source: Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling
stated in qid: Q24312963
retrieved: 2019-05-09

source: Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse
stated in qid: Q28585819
retrieved: 2019-05-09

source: Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
stated in qid: Q28590748
retrieved: 2019-05-09

source: Parkin-deficient mice are not a robust model of parkinsonism
stated in qid: Q28504677
retrieved: 2019-05-09

source: Cannabinoid CB(1) receptors in the basal ganglia and motor response to activation or blockade of these receptors in parkin-null mice
stated in qid: Q28585963
retrieved: 2019-05-09

source: Loss of locus coeruleus neurons and reduced startle in parkin null mice
stated in qid: Q28593443
retrieved: 2019-05-09

source: The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO
stated in qid: Q24321825
retrieved: 2019-05-09

source: Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation
stated in qid: Q28510558
retrieved: 2019-05-09

source: Memory and exploratory impairment in mice that lack the Park-2 gene and that over-express the human FTDP-17 mutant Tau
stated in qid: Q28589996
retrieved: 2019-05-09

source: Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
stated in qid: Q28593859
retrieved: 2019-05-09

source: Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress
stated in qid: Q24309549
retrieved: 2019-05-09

source: MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin
stated in qid: Q24298771
retrieved: 2019-05-09

wikidata id: Q14864264
domain: protein
level: standard
html url: https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q14864264
markdown url: https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q14864264.md
facts url summary: https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q14864264/facts.json
facts url standard: https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q14864264/facts.json
facts url full: https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q14864264/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T01:22:32.118057Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T14:23:25.121472+00:00Z