# Parkin RBR E3 ubiquitin protein ligase

> mammalian protein found in Mus musculus

**Wikidata**: [Q14864264](https://www.wikidata.org/wiki/Q14864264)  
**Source**: https://4ort.xyz/entity/parkin-rbr-e3-ubiquitin-protein-ligase-q14864264


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q9WVS6)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WVS6&geneProductId=UniProtKB:Q9WVS6)
6. [SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WVS6&geneProductId=UniProtKB:Q9WVS6)
7. [PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
8. [A Product of the Human Gene Adjacent to parkin Is a Component of Lewy Bodies and Suppresses Pael Receptor-induced Cell Death](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
9. [Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
10. [SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
11. [Loss of laforin or malin results in increased Drp1 level and concomitant mitochondrial fragmentation in Lafora disease mouse models](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
12. [Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
13. [14-3-3eta is a novel regulator of parkin ubiquitin ligase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
14. [Parkin ubiquitinates and promotes the degradation of RanBP2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
16. [Identification of the Ubiquitin-like Domain of Midnolin as a New Glucokinase Interaction Partner](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WVS6&geneProductId=UniProtKB:Q9WVS6)
17. [Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WVS6&geneProductId=UniProtKB:Q9WVS6)
18. [Identification of the Ubiquitin-like Domain of Midnolin as a New Glucokinase Interaction Partner](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
19. [Differential expression and tissue distribution of parkin isoforms during mouse development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
20. [Parkin occurs in a stable, non-covalent, approximately 110-kDa complex in brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
21. [Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
22. [Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
23. [Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
24. [Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
25. [Parkin-deficient mice are not a robust model of parkinsonism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
26. [Cannabinoid CB(1) receptors in the basal ganglia and motor response to activation or blockade of these receptors in parkin-null mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
27. [Loss of locus coeruleus neurons and reduced startle in parkin null mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
28. [The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
29. [Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
30. [Memory and exploratory impairment in mice that lack the Park-2 gene and that over-express the human FTDP-17 mutant Tau](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
31. [Mitochondrial dysfunction and oxidative damage in parkin-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
32. [Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
33. [MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
34. [The diabetes susceptibility gene Clec16a regulates mitophagy](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WVS6)
35. ensembl Release 93