Par-3 family cell polarity regulator
type: Thing
description: mammalian protein found in Mus musculus
additional property: PropertyValue
  property ID: P31
  value: protein
additional property: PropertyValue
  property ID: P361
  value: PDZ superfamily
additional property: PropertyValue
  property ID: P361
  value: membrane protein
additional property: PropertyValue
  property ID: P361
  value: PDZ domain, protein family
additional property: PropertyValue
  property ID: P527
  value: Par3/HAL, N-terminal
additional property: PropertyValue
  property ID: P527
  value: PDZ domain
additional property: PropertyValue
  property ID: P637
  value: NP_001013598
additional property: PropertyValue
  property ID: P637
  value: NP_001013599
additional property: PropertyValue
  property ID: P637
  value: NP_001116322
additional property: PropertyValue
  property ID: P638
  value: 2KOH
additional property: PropertyValue
  property ID: P638
  value: 2KOJ
additional property: PropertyValue
  property ID: P680
  value: protein binding
additional property: PropertyValue
  property ID: P680
  value: protein kinase C binding
additional property: PropertyValue
  property ID: P680
  value: lipid binding
additional property: PropertyValue
  property ID: P681
  value: cytoplasm
additional property: PropertyValue
  property ID: P681
  value: membrane
additional property: PropertyValue
  property ID: P681
  value: cell-cell junction
additional property: PropertyValue
  property ID: P682
  value: cell differentiation
additional property: PropertyValue
  property ID: P682
  value: positive regulation of receptor internalization
additional property: PropertyValue
  property ID: P682
  value: centrosome localization
additional property: PropertyValue
  property ID: P702
  value: Pard3
additional property: PropertyValue
  property ID: P703
  value: house mouse
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000104383
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000125612
additional property: PropertyValue
  property ID: P705
  value: ENSMUSP00000026921
confidence:
  popularity graph score:
    score: 0.004
    score pct: 0
    tier: established
    components:
      sitelinks: 0
      sitelinks norm: 0.0
      unique citations: 26
      unique citations norm: 0.01
      monthly pageviews: 0
      monthly pageviews norm: 0.0
  sitelinks: 0
  unique citations: 26
  monthly pageviews: 0
  yearly pageviews: 0
  tier: established
claims:
  P31:
    value: Q8054
    source count: 1
    confidence: 0.2
    value label: protein
  P352:
    value: Q99NH2
    source count: 1
    confidence: 0.2
  P361:
    value: Q41797172
    source count: 1
    confidence: 0.2
    value label: PDZ superfamily
  P361:
    value: Q423042
    source count: 1
    confidence: 0.2
    value label: membrane protein
  P361:
    value: Q83132799
    source count: 1
    confidence: 0.2
    value label: PDZ domain, protein family
  P361:
    value: Q83134908
    source count: 1
    confidence: 0.2
    value label: Par3/HAL, N-terminal domain, protein family
  P527:
    value: Q24724736
    source count: 1
    confidence: 0.2
    value label: Par3/HAL, N-terminal
  P527:
    value: Q24721050
    source count: 1
    confidence: 0.2
    value label: PDZ domain
  P637:
    value: NP_001013598
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001013599
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001116322
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001296320
    source count: 1
    confidence: 0.2
  P637:
    value: NP_001296321
    source count: 1
    confidence: 0.2
  P638:
    value: 2KOH
    source count: 1
    confidence: 0.2
  P638:
    value: 2KOJ
    source count: 1
    confidence: 0.2
  P680:
    value: Q167149
    source count: 5
    confidence: 1.0
    value label: protein binding
  P680:
    value: Q14890003
    source count: 1
    confidence: 0.2
    value label: protein kinase C binding
  P680:
    value: Q14358833
    source count: 1
    confidence: 0.2
    value label: lipid binding
  P680:
    value: Q14873950
    source count: 2
    confidence: 0.4
    value label: phosphatidylinositol-4,5-bisphosphate binding
  P680:
    value: Q14906038
    source count: 2
    confidence: 0.4
    value label: phosphatidylinositol-3,4,5-trisphosphate binding
  P681:
    value: Q79899
    source count: 2
    confidence: 0.4
    value label: cytoplasm
  P681:
    value: Q14349455
    source count: 1
    confidence: 0.2
    value label: membrane
  P681:
    value: Q14873267
    source count: 3
    confidence: 0.6
    value label: cell-cell junction

value: Q14883308
source count: 4
confidence: 0.8
value label: bicellular tight junction

value: Q29548
source count: 1
confidence: 0.2
value label: plasma membrane

value: Q210861
source count: 1
confidence: 0.2
value label: cell differentiation

value: Q14901679
source count: 1
confidence: 0.2
value label: positive regulation of receptor internalization

value: Q21097553
source count: 1
confidence: 0.2
value label: centrosome localization

value: Q14904365
source count: 1
confidence: 0.2
value label: negative regulation of peptidyl-threonine phosphorylation

value: Q21109324
source count: 1
confidence: 0.2
value label: regulation of actin filament-based process

value: Q18270191
source count: 1
confidence: 0.2
value label: Pard3

value: Q83310
source count: 1
confidence: 0.2
value label: house mouse

value: ENSMUSP00000104383
source count: 1
confidence: 0.2

value: ENSMUSP00000125612
source count: 1
confidence: 0.2

value: ENSMUSP00000026921
source count: 1
confidence: 0.2

value: ENSMUSP00000078710
source count: 1
confidence: 0.2

value: ENSMUSP00000123944
source count: 1
confidence: 0.2

source: Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling
stated in qid: Q24338727
retrieved: 2019-02-14

source: The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1
stated in qid: Q24290129
retrieved: 2019-02-14

source: Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration
stated in qid: Q28590412
retrieved: 2019-02-14

source: FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex
stated in qid: Q28505884
retrieved: 2019-02-14

source: Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice
stated in qid: Q28588532
retrieved: 2019-02-14

source: Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin
stated in qid: Q28587207
retrieved: 2018-04-24

source: GOA
stated in qid: Q28018111
retrieved: 2019-02-14

source: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
stated in qid: Q34211397
retrieved: 2019-02-14

source: GOA
stated in qid: Q28018111
retrieved: 2018-04-24

source: PAR-3 defines a central subdomain of the cortical actin cap in mouse eggs
stated in qid: Q28509592
retrieved: 2018-04-24

source: E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
stated in qid: Q28593264
retrieved: 2019-02-14

source: PAR-3 defines a central subdomain of the cortical actin cap in mouse eggs
stated in qid: Q28509592
retrieved: 2019-02-14

source: Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves
stated in qid: Q28573119
retrieved: 2019-02-14

source: Nectins localize Willin to cell–cell junctions
stated in qid: Q28507837
retrieved: 2018-04-24

source: FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex
stated in qid: Q28505884
retrieved: 2018-04-24

source: Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells
stated in qid: Q28589354
retrieved: 2018-04-24

source: Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells
stated in qid: Q28589354
retrieved: 2019-02-14

source: Nectins localize Willin to cell–cell junctions
stated in qid: Q28507837
retrieved: 2019-02-14

source: Spatial regulation of VEGF receptor endocytosis in angiogenesis
stated in qid: Q28585752
retrieved: 2019-02-14

source: Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation
stated in qid: Q28590637
retrieved: 2019-02-14

source: Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration
stated in qid: Q28590412
retrieved: 2018-04-24

source: Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse
stated in qid: Q28201973
retrieved: 2019-02-14

source: InterPro Release 71.0
stated in qid: Q58943792

source: UniProt
stated in qid: Q905695
retrieved: 2022-05-25

source: Q20641742
stated in qid: Q20641742
retrieved: 2022-03-20

source: ensembl Release 106
stated in qid: Q111699881

wikidata id: Q21987386
domain: protein
level: standard
html url: https://4ort.xyz/entity/par-3-family-cell-polarity-regulator-q21987386
markdown url: https://4ort.xyz/entity/par-3-family-cell-polarity-regulator-q21987386.md
facts url summary: https://4ort.xyz/entity/par-3-family-cell-polarity-regulator-q21987386/facts.json
facts url standard: https://4ort.xyz/entity/par-3-family-cell-polarity-regulator-q21987386/facts.json
facts url full: https://4ort.xyz/entity/par-3-family-cell-polarity-regulator-q21987386/facts.json
data source: Wikidata (CC0 / public domain)
license: https://creativecommons.org/publicdomain/zero/1.0/
api version: v1
served at: 2026-08-02T17:02:59.221374Z
entity updated at: 2026-05-03T18:28:36.114423+00:00Z
entity created at: 2026-05-03T15:26:07.980114+00:00Z