# Pancreatic and duodenal homeobox 1

> mammalian protein found in Mus musculus

**Wikidata**: [Q21989355](https://www.wikidata.org/wiki/Q21989355)  
**Source**: https://4ort.xyz/entity/pancreatic-and-duodenal-homeobox-1


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P52946)
3. Q20641742
4. [Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
5. [The nucleosome binding protein HMGN3 modulates the transcription profile of pancreatic beta cells and affects insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
6. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
7. [The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
8. [Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
9. [Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
10. [MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
11. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
12. [Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
13. [Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
14. [RB regulates pancreas development by stabilizing Pdx1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
15. [Cell-specific expression of glucose-dependent-insulinotropic polypeptide is regulated by the transcription factor PDX-1](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
16. [Conserved transcriptional regulatory domains of the pdx-1 gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
17. [Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
18. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
19. [Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
20. [Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
21. [Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
22. [Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
23. [The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
24. [Conversion of biliary system to pancreatic tissue in Hes1-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
25. [pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
26. [Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
27. [pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
28. [Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
29. [Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
30. [Conversion of biliary system to pancreatic tissue in Hes1-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
31. [The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
32. [Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
33. [Sox17 regulates organ lineage segregation of ventral foregut progenitor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
34. [Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
35. [The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
36. [Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
37. [An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
38. [The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
39. [Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
40. [PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
41. [Conserved transcriptional regulatory domains of the pdx-1 gene](http://www.ebi.ac.uk/QuickGO/annotations?protein=P52946&geneProductId=UniProtKB:P52946)
42. [PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52946)
43. ensembl Release 106