# Pancreatic and duodenal homeobox 1

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28559034](https://www.wikidata.org/wiki/Q28559034)  
**Source**: https://4ort.xyz/entity/pancreatic-and-duodenal-homeobox-1-q28559034


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P52947)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
5. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
6. [Pax6 and Pdx1 form a functional complex on the rat somatostatin gene upstream enhancer](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
7. [Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
8. [Oligonucleotide microarray analysis reveals PDX1 as an essential regulator of mitochondrial metabolism in rat islets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
9. [The coactivator Bridge-1 increases transcriptional activation by pancreas duodenum homeobox-1 (PDX-1)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
10. [Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
11. [The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
12. [Insulin Gene Transcription Is Mediated by Interactions between the p300 Coactivator and PDX-1, BETA2, and E47](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
13. [Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
14. [The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
15. [Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
16. [Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
17. [Co-localization of nestin and PDX-1 in small evaginations of the main pancreatic duct in adult rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
18. [NKX6.1 Promotes PDX-1-Induced Liver to Pancreatic β-Cells Reprogramming](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
19. [A Comprehensive Analysis of Cytokine-induced and Nuclear Factor-κB-dependent Genes in Primary Rat Pancreatic β-Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
20. [Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
21. [Pancreatic homeodomain transcription factor IDX1/IPF1 expressed in developing brain regulates somatostatin gene transcription in embryonic neural cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
22. [PDX:PBX complexes are required for normal proliferation of pancreatic cells during development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
23. [PDX-1 expression is associated with islet proliferation in vitro and in vivo](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
24. [Involvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucose](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
25. [Enhanced beta-cell mass without increased proliferation following chronic mild glucose infusion](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
26. [Decreased sucrase and lactase activity in iron deficiency is accompanied by reduced gene expression and upregulation of the transcriptional repressor PDX-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
27. [Regulation of pancreatic endocrine cell differentiation by sulphated proteoglycans](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
28. [Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
29. [Beta-cell maturation leads to in vitro sensitivity to cytotoxins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
30. [AMP-activated protein kinase and pancreatic/duodenal homeobox-1 involved in insulin secretion under high leucine exposure in rat insulinoma beta-cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
31. [Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
32. [Expression of Groucho/TLE proteins during pancreas development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
33. [PDX-1 expression and proliferation of duct epithelial cells after partial pancreatectomy in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
34. [Different mechanisms operating during different critical time-windows reduce rat fetal beta cell mass due to a maternal low-protein or low-energy diet](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
35. [Coexpression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
36. [Effects of biotin on glucotoxicity or lipotoxicity in rat pancreatic islets](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
37. [Cyclical and alternating infusions of glucose and intralipid in rats inhibit insulin gene expression and Pdx-1 binding in islets.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
38. [Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
39. [Prenatal nicotine exposure alters early pancreatic islet and adipose tissue development with consequences on the control of body weight and glucose metabolism later in life](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
40. [Promotion of beta-cell differentiation by conophylline in fetal and neonatal rat pancreas](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
41. [Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
42. [Adeno-associated virus-mediated pancreatic and duodenal homeobox gene-1 expression enhanced differentiation of hepatic oval stem cells to insulin-producing cells in diabetic rats](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
43. [Insulin-producing cells derived from rat bone marrow and their autologous transplantation in the duodenal wall for treating diabetes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
44. [Dissecting the role of glucocorticoids on pancreas development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
45. [Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
46. [Palmitic acid increase levels of pancreatic duodenal homeobox-1 and p38/stress-activated protein kinase in islets from rats maintained on a low protein diet](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P52947)
47. ensembl Release 106