# Palmitoyl-protein thioesterase 1

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21134385](https://www.wikidata.org/wiki/Q21134385)  
**Source**: https://4ort.xyz/entity/palmitoyl-protein-thioesterase-1-q21134385


## References

1. UniProt
2. [BioGRID](https://thebiogrid.org/news/227)
3. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P50897)
4. Q20641742
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
6. [In vitro depalmitoylation of neurospecific peptides: implication for infantile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
7. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
8. [Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
9. [Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
10. [In vitro depalmitoylation of neurospecific peptides: implication for infantile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
11. [Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
12. [Global Mapping of Herpesvirus-Host Protein Complexes Reveals a Transcription Strategy for Late Genes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
13. [Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
14. [Palmitoyl protein thioesterase 1 protects against apoptosis mediated by Ras-Akt-caspase pathway in neuroblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
15. [Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
16. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
17. [Differential regulation of ceramide in lipid-rich microdomains (rafts): antagonistic role of palmitoyl:protein thioesterase and neutral sphingomyelinase 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
18. [Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
19. [Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
20. [Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
21. [Proteomic analysis of podocyte exosome-enriched fraction from normal human urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
22. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
23. [CLN-1 and CLN-5, genes for infantile and variant late infantile neuronal ceroid lipofuscinoses, are expressed in the embryonic human brain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
24. [Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
25. [Palmitoyl protein thioesterase 1 is targeted to the axons in neurons](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
26. [Antisense palmitoyl protein thioesterase 1 (PPT1) treatment inhibits PPT1 activity and increases cell death in LA-N-5 neuroblastoma cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
27. [Palmitoyl protein thioesterase 1 is targeted to the axons in neurons](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
28. [Defining the membrane proteome of NK cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
29. [In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
30. [Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
31. [Elevated lysosomal pH in neuronal ceroid lipofuscinoses (NCLs)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
32. [Palmitoyl protein thioesterase (PPT) localizes into synaptosomes and synaptic vesicles in neurons: implications for infantile neuronal ceroid lipofuscinosis (INCL)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
33. [Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing](http://www.ebi.ac.uk/QuickGO/annotations?protein=P50897&geneProductId=UniProtKB:P50897)
34. [Lipid thioesters derived from acylated proteins accumulate in infantile neuronal ceroid lipofuscinosis: correction of the defect in lymphoblasts by recombinant palmitoyl-protein thioesterase](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
35. [Batten's disease: clues to neuronal protein catabolism in lysosomes](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50897)
36. Ensembl Release 99