# paired box 8

> mammalian protein found in Homo sapiens

**Wikidata**: [Q21120164](https://www.wikidata.org/wiki/Q21120164)  
**Wikipedia**: [English](https://en.wikipedia.org/wiki/PAX8)  
**Source**: https://4ort.xyz/entity/paired-box-8


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/Q06710)
3. Q20641742
4. [PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
5. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
6. [PAX8-mediated activation of the wt1 tumor suppressor gene](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
7. [Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
8. [Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
9. [PAX 8 Regulates Human WT1 Transcription through a Novel DNA Binding Site](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
10. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06710&geneProductId=UniProtKB:Q06710)
11. [TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
12. [A Comprehensive Resource of Interacting Protein Regions for Refining Human Transcription Factor Networks](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
13. [PAX 8 Regulates Human WT1 Transcription through a Novel DNA Binding Site](http://www.ebi.ac.uk/QuickGO/annotations?protein=Q06710&geneProductId=UniProtKB:Q06710)
14. [A census of human transcription factors: function, expression and evolution](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
15. [PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
16. [PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
17. [Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
18. [Characterization of a novel loss of function mutation of PAX8 in a familial case of congenital hypothyroidism with in-place, normal-sized thyroid](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
19. [PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q06710)
20. Ensembl Release 99
21. UMLS 2023
22. [OpenAlex](https://docs.openalex.org/download-snapshot/snapshot-data-format)