# Paired box 8

> mammalian protein found in Rattus norvegicus

**Wikidata**: [Q28558478](https://www.wikidata.org/wiki/Q28558478)  
**Source**: https://4ort.xyz/entity/paired-box-8-q28558478


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P51974)
3. Q20641742
4. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51974)
5. [Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51974)
6. [Oxidoreductive modification of two cysteine residues in paired domain by Ref-1 regulates DNA-binding activity of Pax-8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51974)
7. [Glutathionylation of two cysteine residues in paired domain regulates DNA binding activity of Pax-8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51974)
8. [The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51974)
9. [WBP-2, a WW domain binding protein, interacts with the thyroid-specific transcription factor Pax8](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51974)
10. [Pax-8 is essential for regulation of the thyroglobulin gene by transforming growth factor-beta1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51974)
11. [TTF-2, a new forkhead protein, shows a temporal expression in the developing thyroid which is consistent with a role in controlling the onset of differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51974)
12. ensembl Release 106