# Paired box 6

> mammalian protein found in Mus musculus

**Wikidata**: [Q14916221](https://www.wikidata.org/wiki/Q14916221)  
**Source**: https://4ort.xyz/entity/paired-box-6


## References

1. UniProt
2. [InterPro Release 71.0](http://www.ebi.ac.uk/interpro/protein/P63015)
3. Q20641742
4. [Pax genes and their role in organogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
5. [Pax6 directly modulate Sox2 expression in the neural progenitor cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
6. [Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6](http://www.ebi.ac.uk/QuickGO/annotations?protein=P63015&geneProductId=UniProtKB:P63015)
7. [Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
8. [The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
9. [The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
10. [The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
11. [Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
12. [Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
13. [The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
14. [Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
15. [Paired Related Homeobox Protein 1 is a Regulator of Stemness in Adult Neural Stem/Progenitor Cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
16. [A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
17. [Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
18. [Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
19. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
20. [Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
21. [Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
22. [Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition–like mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
23. [Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
24. [Mouse model reveals the role of RERE in cerebellar foliation and the migration and maturation of Purkinje cells](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
25. [Pancreas-enriched miRNA refines endocrine cell differentiation](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
26. [Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
27. [Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
28. [The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
29. [Coordinated expression of Hoxa2, Hoxd1 and Pax6 in the developing diencephalon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
30. [Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
31. [Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
32. [Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion](http://www.ebi.ac.uk/QuickGO/annotations?protein=P63015&geneProductId=UniProtKB:P63015)
33. [Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
34. [Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
35. [Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
36. [Emx1, emx2 and pax6 in specification, regionalization and arealization of the cerebral cortex](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
37. [The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
38. [The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
39. [Pax6 is essential for establishing ventral-dorsal cell boundaries in pituitary gland development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
40. [Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
41. [Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/- mouse model of aniridia](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
42. [Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
43. [Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate.](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
44. [Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
45. [ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
46. [GOA](http://www.ebi.ac.uk/QuickGO/annotations?protein=P63015&geneProductId=UniProtKB:P63015)
47. [Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
48. [FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
49. [Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)
50. [Further genetic analysis of two autosomal dominant mouse eye defects, Ccw and Pax6(coop)](http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63015)